Fig. 2

DLGAP1: gene structure, levels in CML and effects on cell growth. a Schematic of DLGAP1 gene structure with blue bars representing exons and red arrows indicating 3 independent RISs localization. Distances between the rescued RISs are given below. b Bar graph of relative DLGAP1 mRNA levels in different phases of CML from FHCRC patient database: 1 chronic phase, 2 accelerated phase, 3 blast crisis (modified from Oncomine.org). c Effect of DLGAP1 isoforms on growth of MPL driven cell lines. Left panel: line graph of the growth of K562 cells driven by inducible MPL construct and overexpressing the full length and truncated isoform of DLGAP1. Right panel: UT7/TPO cells supplemented with rhMGDF and overexpressing the full length DLGAP1 from pE-DLGAP1 vector and its truncated form from the pE-Tr-DLGAP1 vector