Fig. 7
Role of IL-1 pathway blockade on the anti-tumor efficacy of cetuximab. Female athymic (nu/nu) mice bearing SQ20B xenograft tumors were treated with 2 mg/mouse cetuximab (CTX) twice/week i.p. with or without anakinra (IL-1RA) administered at 10 mg/kg daily i.p. for 3 weeks. IgG and PBS were used as controls. N = 6 mice/treatment group. Error bars represent ± SEM. *p < 0.05 versus control; **p < 0.05 versus CTX