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Table 2 Ongoing trials of inotuzumab ozogamicin (INO)

From: Inotuzumab ozogamicin in clinical development for acute lymphoblastic leukemia and non-Hodgkin lymphoma

Reference Phase Disease Intervention Recruitment
NCT03441061 2 B-ALL with positive MRD INO Recruiting
NCT03677596 4 R/R B-ALL Investigating lower dose level (1.2 mg/m2/cycle) for those with higher risk for liver toxicity or VOD. Not yet recruiting
NCT03460522 2 Precursor B-cell ALL in 56–74 years old INO induction followed by conventional chemotherapy Recruiting
NCT02311998 1/ 2 Ph + B-ALL and CML-blast phase Bosutinib plus INO Recruiting
NCT01925131 1 Acute leukemia of ambiguous lineage, Recurrent Ph + B-ALL, Recurrent Burkitt Lymphoma INO plus CVP (cyclophosphamide, Vincristine, Prednisone) Recruiting
NCT03739814 2 Ph negative B-ALL INO followed by Blinatumomab Recruiting
NCT03851081 1/ 2 r/r B-ALL INO plus Vincristine (liposomal) Not yet Recruiting
NCT01664910 1/ 2 Conditioning regimen for HSCT INO + plus Rituximab, Bendamustine and Fludarabine Recruiting
NCT03249870 2 Ph negative B-ALL in 55 years or older INO plus CVP induction Recruiting
NCT03610438 2 ALL with positive MRD prior to HSCT INO Not yet recruiting
NCT03856216 2 Allogeneic SCT Pre and Post HSCT INO Not yet recruiting
NCT01371630 1/ 2 Untreated ALL in 60 years and older INO plus combination chemotherapy Not yet recruiting
NCT03150693 3 Newly diagnosed B-ALL in 18–39 years old INO plus chemotherapy Recruiting
NCT03094611 2 R/R ALL Lower dose INO Recruiting
NCT03488225 2 ALL INO plus HyperCVAD Recruiting
NCT01679119 2 DLBCL INO plus R-CVP versus
NCT02981628 2 B-ALL in 1–21 years old INO Recruiting
NCT03628053 3 ALL Tisagenlecleucel versus Blinatumomab or Inotuzumab Not yet recruiting
  1. Abbreviations: R/R refractory /relapsed, CVAD cyclophosphamide vincristine Adriamycin dexamethasone, NHL non-Hodgkin lymphoma, DLBCL diffuse large B cell lymphoma, ALL acute lymphoblastic leukemia, Gem gemcitabine, R rituximab, CVP cyclophosphamide vincristine prednisone, VOD veno-occlusive disease