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Table 2 Clinical trials of MSCs exosomes–based therapies

From: Exosomes from mesenchymal stem/stromal cells: a new therapeutic paradigm

Study title Disease Intervention Phase NCT
Allogenic Mesenchymal Stem Cell-Derived Exosome in Patients With Acute Ischemic Stroke Cerebrovascular Disorders Biological: exosome Phase 1
Phase 2
NCT03384433
MSC-Exos Promote Healing of MHs Macular Holes Biological: exosomes derived from mesenchymal stem cells (MSC-Exo) Early Phase 1 NCT03437759
microRNAs Role in Pre-eclampsia Diagnosis Preeclampsia Biological: exosome Complete NCT03562715
Effect of Microvesicles and Exosomes Therapy on β-cell Mass in Type I Diabetes Mellitus (T1DM) Diabetes Mellitus Type 1 Biological: MSC exosomes. Phase 2
Phase 3
NCT02138331
Trial of a Vaccination With Tumor Antigen-loaded
Dendritic Cell-derived Exosomes
Non Small Cell Lung Cancer Biological: Dex2 Phase 2 NCT01159288
Serum Exosomal Long Noncoding RNAs as Biomarkers for Lung Cancer Diagnosis Lung Cancer (Diagnosis) Diagnostic Test: collect samples   NCT03830619