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Table 1 The function of MSC-derived exosomes

From: Exosomes from mesenchymal stem/stromal cells: a new therapeutic paradigm

Source of Exosomes Specific Disease Treated Target/Pathway Reference
human umbilical cord MSCs liver fibrosis TGF-β1/Smad2 [30]
HuES9.E1 MSC hepatoprotective effects Cyclin D1, Bcl-xL, STAT3 [31]
adipose derived-MSCs hepatitis TNF-α, IFN-γ, IL-6, IL-18 and IL-1β [33]
human umbilical cord-derived MSCs renal Ischemia-reperfusion injury (IRI) VEGF [34]
adipose tissue-derived autologous MSCs renal artery stenosis TNF-α, IL-6, IL10 and IL-1-β [35]
human bone marrow MSCs acute kidney injury mRNAs [36]
bone marrow MSCs acute renal injury Bcl-xL,Bcl2, BIRC8,Casp1, Casp8 and LTA [37]
human umbilical cord MSCs unilateral renal ischemia lipocalin [38]
bone marrow MSCs acute kidney injury mRNAs [36]
Human bone marrow MSCs damaged renal tubular IGF-1R [39]
adipose-derived MSC myocardial ischemia-reperfusion injury Wnt/β-catenin [41]
endometrium-derived MSCs myocardial infarction miR-21, PTEN [42]
HuES9.E1 derived MSCs myocardial ischemia/reperfusion injury PI3K/Akt [43]
mouse bone marrow-derived MSCs myocardial infarction miR-22, Mecp2 [44]
bone marrow MSCs myocardial infarction miR-125b [45]
human mesenchymal stem cell cardiac contractility miR-21-5p, PI3K [46]
bone marrow-derived MSCs myocardial ischaemia reperfusion injury AMPK/mTOR, Akt/mTOR [47]
rat bone marrow derived MSCs stroke miR-17-92, PTEN [50]
human adipose tissue-derived MSCs Alzheimer’s disease neprilysin [51]
adipose-derived stem cells oxygen-glucose deprivation MicroRNA-181b/TRPM7 [52]
mouse bone marrow MSCs Alzheimer’s disease STAT3, NF-κB [53]
bone marrow derived MSCs chronic graft-versus-host disease Treg, Th17 [55]
human multipotent stromal cells type 1 diabetes, uveoretinitis Th1, Th17 [56]
human bone-marrow derived MSCs asthma IL-10, TGF-β1 [57]
human umbilical cord MSCs inflammation MiR-181c, TLR4 [58]