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Table 2 Methylation summary of whole genome bisulphite sequencing

From: Reduced nuclear DNA methylation and mitochondrial transcript changes in adenomas do not associate with mtDNA methylation

 

Normal mucosa (n = 5)

Adenoma (n = 4)

Nuclear Genome

CG methylation %

74.5 ± 0.50

67.9 ± 1.16*

CHG methylation %

1.3 ± 0.06

1.0 ± 0.05

CHH methylation %

1.3 ± 0.07

1.0 ± 0.05

Mitochondrial Genome

CG methylation %

1.0 ± 0.09

1.0 ± 0.16

CHG methylation %

1.3 ± 0.14

0.8 ± 0.14

CHH methylation %

1.2 ± 0.06

0.92 ± 0.12

Lambda control % unconverted cytosines

1.06 ± 0.06

0.86 ± 0.05

  1. Average methylation percentage ± SEM, *P < 0.01 Normal vs Adenoma. No statistical tests were performed on methylation levels within the range of the lambda controls (which indicate conversion efficiency)