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Fig. 1 | Biomarker Research

Fig. 1

From: Reduced nuclear DNA methylation and mitochondrial transcript changes in adenomas do not associate with mtDNA methylation

Fig. 1

Comparison of mtDNA-transcript levels in 8 adenomas compared to 4 matched normal mucosal samples revealed that transcript levels of 2 protein coding genes and 3 tRNAs are reduced in adenomas. 100% means no change between normal and paired adenoma. Average of 8 comparisons +/-SEM shown. Only tRNAs that had sequence reads are displayed. *P < 0.05, **P < 0.009 normal vs adenoma. After Benjamini-Hochberg correction, MT-CO1 and MT-ND5 were just outside the critical value (Q = 0.053, and 0.066 respectively). MT-ND1–6, NADH dehydrogenase subunits 1–6; MT-CO1–3, Cytochrome c oxidase subunits I-III; MT-CYB, Cytochrome b; MT-ATP6, ATP synthase Fo subunit 6; MT-ATP8, ATP synthase protein 8; MT-RNR2, mitochondrial ribosomal 16S RNA; MT-RNR1, MT-TN, tRNA asparagine; MT-TC, tRNA cysteine; MT-TK, tRNA lysine; MT-TP tRNA proline; mitochondrial ribosomal 12S RNA

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