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Fig. 1 | Biomarker Research

Fig. 1

From: OPCML is hypermethylated in a subset of patients with metaplastic changes in their esophagus

Fig. 1

OPCML methylation in normal esophageal samples or from patients within the EAC cascade. Position 1 (a), position 2 (b), and position 3 (c) within the first exon of OPCML. d OPCML methylation at position 1 across the 20 patients with GM. Site of GM was analyzed. Position 1 was shown as representative results across the three positions. e OPCML methylation at position 1 across the 11 patients with GM. Both normal and GM tissue were analyzed from the same patient. Patients corresponded to P1–11 in Panel D. Patterns were consistent for positions 2 and 3. f OPCML methylation at positions 1, 2 and 3 for the normal, GM and EAC tissues within the same EAC patient (n = 3 replicates across all measurements). Position 1: hg19_chr11:133402185; CpG site: cg19151121. *: P < 0.05; **: P < 0.01; ***: P < 0.001. P: Patient; GERD: gastro-esophageal reflux disease; GM: detectable glandular mucosa; EAC: esophageal adenocarcinoma

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