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Fig. 2 | Biomarker Research

Fig. 2

From: Overexpression and cytoplasmic localization of caspase-6 is associated with lamin A degradation in set of ovarian cancers

Fig. 2

a Immuno-chemoluminescence blot showing the profile of cleaved lamin A/C and active caspase-6 in human primary surface epithelial cells (HOSE) in human immortalized surface epithelial cells (HIO80. HIO118) and in ovarian cancer cell lines OVCAR3, OVCAR4, OVCAR5, OVCAR10, ES2, A2780 and A1847. HOSE and proliferating HIO cells had no or weak cleaved lamin A/C and no or weak cleaved caspase-6 (active caspase-6). Ovarian cancer cells had high level of cleaved caspase-6 and cleaved lamin A/C. b Immuno-chemoluminescence blot showing the expression of lamin A/C and active caspase-6 in human primary surface epithelial cells (HOSE) in human immortalized surface epithelial cells (HIO80) and in ovarian cancer cell lines ES2, OVCAR2, OVCAR3, OVCAR4, OVCAR5 and A2780. HOSE cells had high level of lamin A/C but no active caspase-6 (cleaved caspase-6) while proliferating HIO and cancer cells had high level of active caspase-6 and weak expression of lamin A/C. Exceptionally OVCAR2 had weak lamin A/C and active caspase-6

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