Aptamer-based search for correlates of plasma and serum water T2: implications for early metabolic dysregulation and metabolic syndrome

Table 2 Most predictive biomarkers and cluster members for plasma water T₂

Protein Name (Uniprot ID)^a	% Inc. MSE^a	Cluster Members
Hepatocyte growth factor (P14210)	9.51	R-spondin-2, Galectin-7
Glucokinase regulatory protein (Q14397)	9.44	Low-density lipoprotein receptor-related protein 1 soluble, T-lymphocyte activation antigen CD86,
Receptor-type tyrosine-protein kinase FLT3 (P36888)	8.34	Complement C4b^b, Discoidin domain-containing receptor 2, Serine/threonine-protein kinase PAK 6, Heterogeneous nuclear ribonucleoprotein A/B
Ephrin-B2 (P52799)	7.52	Leucine-rich repeat transmembrane protein FLRT3, Amphoterin-induced protein 2, Ephrin-A5,NT-3 growth factor receptor, Kallikrein-8, Interleukin-1 receptor type 1, Iduronate 2-sulfatase, CD109 antigen, Cell adhesion molecule 1, SLIT and NTRK-like protein 5, Ephrin type-A receptor 2, Endoglin, Interleukin-22 receptor subunit alpha-2, OX-2 membrane glycoprotein, Semaphorin-6B, Semaphorin-6A, Interferon alpha/beta receptor 1
Bone sialoprotein 2 (P21815)	5.22	Fibrinogen^b, Alpha-1-antichymotrypsin, Antithrombin-III, Endothelial cell-specific molecule 1, Serotransferrin
Histone-lysine N-methyl-transferase EHMT2 (Q96KQ7)	5.13	Metalloproteinase inhibitor 1, Metalloproteinase inhibitor 2, Delta-like protein 4
Fibroblast growth factor 2 (P09038)	5.09	Fibroblast growth factor 4

^aThe most predictive biomarkers are defined as those with ≥5% increase in mean squared error (MSE)
^bIn a prior study, complement C4 (C4c) and fibrinogen were strongly associated with plasma water T₂ [8]

ISSN: 2050-7771