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Table 2 Most predictive biomarkers and cluster members for plasma water T2

From: Aptamer-based search for correlates of plasma and serum water T2: implications for early metabolic dysregulation and metabolic syndrome

Protein Name (Uniprot ID)a % Inc. MSEa Cluster Members
Hepatocyte growth factor (P14210) 9.51 R-spondin-2, Galectin-7
Glucokinase regulatory protein (Q14397) 9.44 Low-density lipoprotein receptor-related protein 1 soluble, T-lymphocyte activation antigen CD86,
Receptor-type tyrosine-protein kinase FLT3 (P36888) 8.34 Complement C4bb, Discoidin domain-containing receptor 2, Serine/threonine-protein kinase PAK 6, Heterogeneous nuclear ribonucleoprotein A/B
Ephrin-B2 (P52799) 7.52 Leucine-rich repeat transmembrane protein FLRT3, Amphoterin-induced protein 2, Ephrin-A5,NT-3 growth factor receptor, Kallikrein-8, Interleukin-1 receptor type 1, Iduronate 2-sulfatase, CD109 antigen, Cell adhesion molecule 1, SLIT and NTRK-like protein 5, Ephrin type-A receptor 2, Endoglin, Interleukin-22 receptor subunit alpha-2, OX-2 membrane glycoprotein, Semaphorin-6B, Semaphorin-6A, Interferon alpha/beta receptor 1
Bone sialoprotein 2 (P21815) 5.22 Fibrinogenb, Alpha-1-antichymotrypsin, Antithrombin-III, Endothelial cell-specific molecule 1, Serotransferrin
Histone-lysine N-methyl-transferase EHMT2 (Q96KQ7) 5.13 Metalloproteinase inhibitor 1, Metalloproteinase inhibitor 2, Delta-like protein 4
Fibroblast growth factor 2 (P09038) 5.09 Fibroblast growth factor 4
  1. aThe most predictive biomarkers are defined as those with ≥5% increase in mean squared error (MSE)
  2. bIn a prior study, complement C4 (C4c) and fibrinogen were strongly associated with plasma water T2 [8]