Fig. 3

Statins exert an inhibitory effect on the cell cycle. YT-INDY cells were treated with either fluvastatin, atorvastatin or vehicle for 72 h, then labeled with propidium iodide and analyzed by flow cytometry. Data reflect a representative experiment. Values represent the percentage of cells in each phase of the cell cycle. a, e Control YT-INDY cells were treated with vehicle only. b, c, g, f YT-INDY cells were treated with either 10 uM or 5 uM atorvastation or fluvastatin alone. d, h YT-INDY cells were treated with either 10 uM of atorvastatin or fluvastatin and 1 mM of mevalonate