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Fig. 5 | Biomarker Research

Fig. 5

From: Kinomic profiling of glioblastoma cells reveals PLCG1 as a target in restricted glucose

Fig. 5

The efficacy of a PLC, but not Raf, inhibitor was increased when GBM cells were grown in restricted glucose. GBM cells isolated the indicated xenografts (a-d) or non-transformed human astrocytes (e) were cultured in standard or low glucose with or without U73122 or DMSO as a vehicle control. Data were normalized to the DMSO control of the appropriate glucose condition at the same time point. *, p < 0.05 with t-test comparison. f No significant difference in efficacy of the Raf inhibitor AZ628 was observed with changes in glucose levels in the media

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