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Table 2 Top ten promising SNPs identified in univariable analysis and the subsequent multivariable analysis under their plausible genetic models

From: Associations of single nucleotide polymorphisms with mucinous colorectal cancer: genome-wide common variant and gene-based rare variant analyses

      Univariable Multivariablee
Genomic location SNP ID (Genotypea) Geneb Information in RegulomeDB Plausible modelc OR (95% CI) p-value OR (95% CI) p-value
Chr6:110750552 rs9481067 (GG) SLC22A16 ND Recessive 4.17 (2.33–7.43) 1.24E-06 4.75 (2.53–8.95) 1.24E-06
Chr3:114121019 rs10511330 (CT + CC) ZBTB20 Minimal binding evidence Dominant 3.77 (2.06–6.81) 1.24E-05 4.85 (2.54–9.23) 1.40E-06
Chr3:114117327 rs16822593 (AG + AA) ZBTB20 ND Dominant 3.70 (2.02–6.68) 1.59E-05 4.83 (2.53–9.20) 1.50E-06
Chr2:179860562 rs13019215 (TC + TT) CCDC141 ND Dominant 0.27 (0.14–0.48) 1.56E-05 0.23 (0.12–0.43) 8.20E-06
Chr2:179867985 rs12471607 (TC + TT) CCDC141 ND Dominant 0.27 (0.14–0.48) 1.65E-05 0.23 (0.12–0.43) 8.42E-06
Chr5:80483574 rs716897 (CT + CC) RASGRF2 Minimal binding evidence Dominant 0.27 (0.15–0.47) 5.33E-06 0.26 (0.14–0.47) 1.12E-05
Chr16:86077637 rs4843335 (AG + AA) intergenic Minimal binding evidence Dominant 4.11 (2.11–7.79) 2.06E-05 4.67 (2.98–9.34) 1.48E-05
Chr6:118634698 rs11968293 (CA + CC) SLC35F1 Minimal binding evidence Dominant 0.28 (0.16–0.50) 1.27E-05 0.26 (0.14–0.48) 1.48E-05
Chr9:131923949 rs4837345 (TT) intergenic Minimal binding evidence Recessive 4.72 (2.40–9.05) 4.00E-06 4.56 (2.24–9.11) 1.97E-05
Chr9:131930494 kgp10457679/ rs10819474d (CC) intergenic Likely to affect binding and linked to expression of a gene target Recessive 4.72 (2.40–9.05) 4.00E-06 4.56 (2.24–9.11) 1.97E-05
  1. aRisk increasing/decreasing genotype. bBased on Ensembl [51] or dbSNP databases [61]. cUnder the recessive genetic model, minor allele homozygous patients are compared to major allele homozygous and heterozygous patients combined. Under the dominant genetic model, minor allele homozygous and heterozygous patients are combined and compared to major allele homozygous patients. dThe rs number for the kgp10457679 polymorphism was obtained from the UCSC genome browser [62]. eMultivariable models adjusted for sex, age at diagnosis, stage, tumor location, and tumor grade. Patients with missing/unknown data for any of these variables were excluded from the analysis. Chr chromosome, CI confidence interval, ND data not available at RegulomeDB, OR odds ratio (compares the odds of having mucinous tumors with the specified genotype(s)a to the odds of having mucinous tumors with the reference (other) genotype(s))