Table 1 Critical miRNAs as potential diagnostic, therapeutic, prognostic targets in PDAC

miR-21

Oncogenic

Up-regulated

PTEN, PDCD4, CDK6, CDKN1A, IL-6R, FAS, TPM1, APAF1, SOCS5

PI3K/AKT

[20,21,22]

miR-34

Tumor suppressor

Down-regulated

NOTCH, BCL2, VEGFA, CCND1, CDK6

p53/p38-MAPK/NOTCH PI3K/AKT

[14, 24, 26]

miR-200 family

Tumor suppressor

Down-regulated

E-cadherin, ZEB, Vimentin

NOTCH, EMT

[14, 20, 23]

Let-7 family

Tumor suppressor

Down-regulated

KRAS, HRAS, LIN28, HMGA2, NF2, TRIM71

EMT, KRAS

[16]

miR-15a

Tumor suppressor

Down-regulated

WANT3A, FGF7, BMI-1

ERK/AKT, EMT

[28, 29]

miR-506

Tumor suppressor

Down-regulated

SPHK1, PI3M

SPHK1/AKT/NF-κB

[31, 32]

miR-221

Oncogenic

Up-regulated

KIT, CDKN1C, CDKN1B

EMT, PKC/NF-κB, PTEN/PI3K/AKT

[14, 21]

miR-96

Tumor suppressor

Down-regulated

KRAS, AKT

KRAS, PI3K/AKT

[14, 15]

miR-17-92

Tumor suppressor

Down-regulated

p21, p57, TBX3

NODAL/ACTIVIN/TGF-1

[18]

miR-145

Tumor suppressor

Down-regulated

KRAS, RREB1

KRAS, PI3K/AKT

[14]

miR-155

Oncogenic

Up-Regulated

TP53INP

Apoptosis, Exosome Synthesis

[30]