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Table 1 Critical miRNAs as potential diagnostic, therapeutic, prognostic targets in PDAC

From: microRNA based prognostic biomarkers in pancreatic Cancer

miRNAs Function Expression in tumor Targets Pathway Ref.
miR-21 Oncogenic Up-regulated PTEN, PDCD4, CDK6, CDKN1A, IL-6R, FAS, TPM1, APAF1, SOCS5 PI3K/AKT [20,21,22]
miR-34 Tumor suppressor Down-regulated NOTCH, BCL2, VEGFA, CCND1, CDK6 p53/p38-MAPK/NOTCH PI3K/AKT [14, 24, 26]
miR-200 family Tumor suppressor Down-regulated E-cadherin, ZEB, Vimentin NOTCH, EMT [14, 20, 23]
Let-7 family Tumor suppressor Down-regulated KRAS, HRAS, LIN28, HMGA2, NF2, TRIM71 EMT, KRAS [16]
miR-15a Tumor suppressor Down-regulated WANT3A, FGF7, BMI-1 ERK/AKT, EMT [28, 29]
miR-506 Tumor suppressor Down-regulated SPHK1, PI3M SPHK1/AKT/NF-κB [31, 32]
miR-221 Oncogenic Up-regulated KIT, CDKN1C, CDKN1B EMT, PKC/NF-κB, PTEN/PI3K/AKT [14, 21]
miR-96 Tumor suppressor Down-regulated KRAS, AKT KRAS, PI3K/AKT [14, 15]
miR-17-92 Tumor suppressor Down-regulated p21, p57, TBX3 NODAL/ACTIVIN/TGF-1 [18]
miR-145 Tumor suppressor Down-regulated KRAS, RREB1 KRAS, PI3K/AKT [14]
miR-155 Oncogenic Up-Regulated TP53INP Apoptosis, Exosome Synthesis [30]