TY - JOUR AU - Southworth, Thomas AU - Mason, Sarah AU - Bell, Alan AU - Ramis, Isabel AU - Calbet, Marta AU - Domenech, Anna AU - Prats, Neus AU - Miralpeix, Montserrat AU - Singh, Dave PY - 2018 DA - 2018/04/11 TI - PI3K, p38 and JAK/STAT signalling in bronchial tissue from patients with asthma following allergen challenge JO - Biomarker Research SP - 14 VL - 6 IS - 1 AB - Inhaled allergen challenges are often used to evaluate novel asthma treatments in early phase clinical trials. Current novel therapeutic targets in asthma include phosphoinositide 3-kinases (PI3K) delta and gamma, p38 mitogen-activated protein kinase (p38) and Janus kinase/Signal Transducer and Activator of Transcription (JAK/STAT) signalling pathways. The activation of these pathways following allergen exposure in atopic asthma patients it is not known. SN - 2050-7771 UR - https://doi.org/10.1186/s40364-018-0128-9 DO - 10.1186/s40364-018-0128-9 ID - Southworth2018 ER -