Fig. 2

The physiological functions and related regulation of EZH2 in cancer pathogenesis. The EZH2 expression and activity in cancer cells is regulated at genetic, transcriptional, post-transcriptional and post-translational levels, which leads to diverse functions of EZH2. EZH2, mediating gene transcriptional silencing and activation, promotes cell survival, proliferation, epithelial to mesenchymal, invasionand drug resistance of cancer cells. The tumor suppressive effects of EZH2 are also identified in several cancers, especially T-ALL, pancreatic cancer and clear cell renal carcinoma. What’s more, EZH2 has decisive roles in T and NK cells mediated immune evasion