Fig. 2

Loss of SphK2 reduces the incidence of B lineage ALL. a-c Kaplan-Meier plots showing all (a) and ALL-induced (b) deaths. Deaths due to causes other than ALL are illustrated in (c). Total WBC (d, left panel) and ALL blast counts (d, right panel) at the time of sacrifice are shown. # indicates p < 0.05. e Mouse culled due to ALL showing enlarged spleen (black arrow). f Blood film from a mouse with ALL showing circulating lymphoblasts. Image acquired using a slide scanner and size bar represents 100 μm. g Section of liver from a mouse culled due to ALL showing both perivascular (thin arrow) and diffuse (thick arrow) infiltration by ALL cells. The degree of infiltration in this animal was typical. Image acquired using slide scanner and size bar indicates 250 μm