Platelet protein biomarker panel for ovarian cancer diagnosis

Biomarker Research

Table 1 Description of the clinical material

Diagnosis and International classification of disease (ICD) coding
Benign lesions		Epithelial ovarian cancer, C56.9
Benign lesions	n	stages I-II	n	stages III-IV	n
Serous ovarian cyst, N82.3	19	serous	2	serous	47
Ovarian fibrom, N82.3	10	mucinous	1	endometrioid	1
Dermoid ovarian cyst, N82.3	5	endometrioid	2	clear-cell	1
Endometriosis cyst, N80.1	8	clear-cell	3
Mucinous ovarian cyst, N83.2	10
Non-cancer ascites, R18.9	1
Paratubar cyst, Q50.5	2
Uterine myom, D25.9	2
Total	57		8		49
Transvaginal sonography, IOTA classification
Ultrasound assessment	Certainty in the assessment			Histopathology	n
Benign	certainly benign			benign	7
Benign	probably benign			benign	16
Benign	uncertain			benign	6
Borderline tumor	uncertain			benign	4
Malignant	probably malignant			benign	2
Malignant	certainly malignant			malignant	1^a
Malignant	certainly malignant			malignant	13^b
no IOTA-based examination				benign	22
no IOTA-based examination				malignant	7^a
no IOTA-based examination				malignant	36^b
Total					114
		Medication:
Comorbidities	n	coagulation/aggregation blockers			n
None	99		none		111
One or few following diseases:	15		Warfarin		1
Breast cancer remission	4		Dabigatran		1
Cardiovascular	14		Aspirin		1
Rheumatic	2		Total		114
Endocrine	4		Experimental setup, n
Astma	2	Method/Statistics	Benign	Ovarian cancer, stage
Hepatitis C	1		lesions	I-II	III-IV
Total	114	2D/PCA	28	8	32
		2D/PLS-DA	25	8	30
		Western blot/PLS-DA	20	8	20
		DigiWest/PLS-DA	29	0	30

ISSN: 2050-7771