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Fig. 1 | Biomarker Research

Fig. 1

From: Platelet protein biomarker panel for ovarian cancer diagnosis

Fig. 1

Proteomics-based analysis of platelet proteins was based on the separation of proteins according to mass (Mr, kDa) and charge (pI) by 2D gel electrophoresis with further analysis of the expression of protein spots for marker identification. a 2D gel electrophoresis diagram of platelet proteins. Circles and numbers indicate the identified biomarkers. b The PLS-DA-based cross-validated model based on the partial least squares discriminate analysis of 2D gels for benign adnexal lesions (white circle) and ovarian cancer, FIGO stage III-IV (black circle) in accordance to the expression of all protein spots in the gel. c Principal component analysis (PCA) showing separation of the generated 2D gels for benign adnexal lesions (white circle), ovarian cancer, FIGO stage I-II (triangle) and FIGO stage III-IV (black circle) in accordance to the expression of selected biomarkers; percentage of variance X explained by the two PCA components shown

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