Development of biomarker combinations for postoperative acute kidney injury via Bayesian model selection in a multicenter cohort study

Table 1 Candidate biomarkers (measured 0–6 h after surgery)

Category	Biomarker	Abbreviation	Source
Biomarkers of kidney injury	Kidney injury molecule-1 [11]	KIM-1	Urine
	Liver fatty acid-binding protein [11]	L-FABP	Urine
	Cystatin C [12]		Urine
	Albumin [10, 13]		Urine
	Neutrophil gelatinase-associated lipocalin [5]	NGAL	Urine, plasma
	Interleukin-18 [5]	IL-18	Urine
Biomarkers of kidney function	Creatinine [5, 14]	Cr	Urine, serum^a
Biomarkers of cardiac function	Heart-type fatty acid binding protein [15]	h-FABP	Plasma
	Brain natriuretic peptide [16]	BNP	Plasma
	High-sensitivity troponin T [16]	TNTHS	Plasma
	N-type pro-B-type natriuretic peptide [16]	NT-proBNP	Plasma
	Creatine kinase-MB [16]	CKMB	Plasma
	Troponin I [16]	TNI	Plasma
Biomarkers of inflammation	Interleukin-6 [7]	IL-6	Plasma
	Interleukin-10 [7]	IL-10	Plasma
	Monocyte chemotactic protein-1 [17]	MCP-1	Plasma
	Epidermal growth factor [17]	EGF	Plasma
	Vascular endothelial growth factor [17]	VEGF	Plasma

^aAlso considered the change from preoperative serum creatinine to 0–6 h postoperative and the average of preoperative and 0–6 h postoperative serum creatinine