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Fig. 1 | Biomarker Research

Fig. 1

From: SALL4 as a transcriptional and epigenetic regulator in normal and leukemic hematopoiesis

Fig. 1

A tentative model for SALL4-regulated epigenetic mechanism in MLL-r leukemia. a Through interacting with MLL fusion oncoprotein, DOT1L, LSD1 and other epigenetic factors, SALL4 may act as a “guide” in modulating the expression levels of specific downstream gene targets. b SALL4-targetd strategies can disrupt MLL fusion oncoprotein function via dysregulated recruitment of essential epigenetic factors

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