Evaluation of two high-throughput proteomic technologies for plasma biomarker discovery in immunotherapy-treated melanoma patients

Table 4 Correlation analysis of Discovery and SOMAScan assays

Cytokine	r value	P value^a	Cytokine	r value	P value^a	Cytokine	r value	P value^a
CTACK	0.0242	0.8719	IL-4	0.1467	0.3252	MCP-4	0.1200	0.4218
EGF	0.2815	0.0553	IL-5	0.1427	0.3387	MDC	0.5461	<0.0001
ENA-78	0.2833	0.0536	IL-6	0.2487	0.0918	MIP-1α	−0.0028	0.9852
Eotaxin-1	0.2312	0.1179	IL-7	−0.0071	0.9618	PDGF-AA	0.7951	<0.0001
Eotaxin-2	0.1752	0.2388	IL-8	0.4526	0.0014	PDGF-BB	0.6449	<0.0001
Eotaxin-3	0.5295	0.0001	IL-9	0.1587	0.2866	RANTES	−0.0445	0.7664
Flt-3 Ligand	0.4585	0.0012	IL-10	−0.2023	0.1727	sCD40L	0.4882	0.0005
Fractalkine	−0.4095	0.0043	IL-13	0.0454	0.7619	SDF-1	0.2765	0.0599
G-CSF	0.0897	0.5486	IL-16	−0.2042	0.1686	TARC	0.8669	<0.0001
GM-CSF	0.1330	0.3727	IL-17A	0.1628	0.2743	TNFα	0.3373	0.0204
GROpan	0.4460	0.0017	IL-20	−0.3942	0.0061	TNFβ	0.3215	0.0275
IFNγ	−0.0659	0.6595	IL-23	−0.1467	0.3252	TPO	0.1433	0.3366
IL-1A	−0.0624	0.6767	IP-10	0.5764	<0.0001	TSLP	−0.0460	0.7587
IL-1B	0.1263	0.3975	I-309	−0.1289	0.3877	VEGF	−0.1383	0.3539
IL-1RA	0.0253	0.8661	MCP-1	0.0614	0.6818	6CKine	0.1104	0.4602
IL-2	−0.467	0.0009	MCP-2	−0.2492	0.0912
IL-3	0.1065	0.4761	MCP-3	−0.2023	0.1728

^aSpearman’s rank correlation coefficient test. Only 12 (shown in bold) of the 49 common proteins showed significant positive correlation between the Discovery and SOMAScan assays (p < 0.05)

ISSN: 2050-7771