TY - JOUR AU - Romay-Tallon, Raquel AU - Rivera-Baltanas, Tania AU - Allen, Josh AU - Olivares, Jose M. AU - Kalynchuk, Lisa E. AU - Caruncho, Hector J. PY - 2017 DA - 2017/09/22 TI - Comparative study of two protocols for quantitative image-analysis of serotonin transporter clustering in lymphocytes, a putative biomarker of therapeutic efficacy in major depression JO - Biomarker Research SP - 27 VL - 5 IS - 1 AB - The pattern of serotonin transporter clustering on the plasma membrane of lymphocytes extracted from human whole blood samples has been identified as a putative biomarker of therapeutic efficacy in major depression. Here we evaluated the possibility of performing a similar analysis using blood smears obtained from rats, and from control human subjects and depression patients. We hypothesized that we could optimize a protocol to make the analysis of serotonin protein clustering in blood smears comparable to the analysis of serotonin protein clustering using isolated lymphocytes. SN - 2050-7771 UR - https://doi.org/10.1186/s40364-017-0107-6 DO - 10.1186/s40364-017-0107-6 ID - Romay-Tallon2017 ER -