TY - JOUR AU - Arko-Boham, Benjamin AU - Lomotey, Justice Tanihu AU - Tetteh, Emmanuel Nomo AU - Tagoe, Emmanuel Ayitey AU - Aryee, Nii Ayite AU - Owusu, Ewurama Ampadu AU - Okai, Isaac AU - Blay, Richard Michael AU - Clegg-Lamptey, Joe-Nat PY - 2017 DA - 2017/06/09 TI - Higher serum concentrations of vimentin and DAKP1 are associated with aggressive breast tumour phenotypes in Ghanaian women JO - Biomarker Research SP - 21 VL - 5 IS - 1 AB - Breast cancer, the most commonly diagnosed cancer among women and leading cause of cancer-related deaths worldwide, exhibits aggressive behavior in indigenous African women evidenced by high histologic grade tumours with low hormone receptor positivity. Aggressive breast cancers grow quickly, easily metastasize and recur and often have unfavourable outcomes. The current study investigated candidate genes that may regulate tumour aggression in Ghanaian women. We hypothesize that increased expression and function of certain genes other than the widely-held view attributing breast cancer aggression in African populations to their younger population age may be responsible for the aggressive nature of tumours. SN - 2050-7771 UR - https://doi.org/10.1186/s40364-017-0100-0 DO - 10.1186/s40364-017-0100-0 ID - Arko-Boham2017 ER -