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Table 3 Univariate and multivariate analysis with respect to distant metastasis-free survival in 121 patients with breast cancer

From: Circulating tumor cell clusters-associated gene plakoglobin is a significant prognostic predictor in patients with breast cancer

Parameter   Univariable analysis Multivariable analysis
Hazard ratio 95% CI p value Hazard ratio 95% CI p value
Intrinsic subtype TNBC vs non-TNBC 1.053 0.281–3.344 0.933 0.632 0.137–2.710 0.535
Intrinsic subtype HER2 vs non-HER2 2.060 0.543–13.41 0.314 1.721 0.353–12.53 0.517
Age at operation ≤56 vs >56 6.096 1.606–39.67 0.006 6.543 1.563–47.40 0.008
Tumor size (cm) ≤2 vs >2 3.234 0.445–40.56 0.049 2.811 0.874–46.08 0.062
Lymph node status Negative vs Positive 4.493 0.873–82.10 0.077 7.035 1.195–137.4 0.028
Nuclear grade 1–2 vs 3 1.805 0.482–5.730 0.353 12.79 1.591–163.3 0.016
Ki67 (%) ≤14 vs >14 2.048 0.652–6.942 0.218 13.99 2.063–203.4 0.005
Pathological response pCR vs non-pCR 2.075 0.619–9.357 0.248 1.561 0.301–10.34 0.609
plakoglobin High vs Low 3.719 1.100–11.66 0.036 7.371 1.596–44.23 0.011
E-cadherin Low vs High 2.223 0.709–7.517 0.169 5.003 0.966–35.14 0.055
  1. HER2 human epidermal growth factor receptor 2; CI confidence interval; pCR pathological complete response; TNBC triple-negative breast cancer