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Table 1 Correlation between clinicopathological features and plakoglobin and E-cadherin expression in 121 patients with breast cancer
| Parameters | plakoglobin | p value | E-cadherin | p value | ||
|---|---|---|---|---|---|---|
| High (n = 21) | Low (n = 100) | High (n = 71) | Low (n = 50) | |||
| HR and HER2 status | ||||||
| TNBC | 4 (19.0%) | 35 (35.0%) | 0.203 | 15 (21.1%) | 24 (48.0%) | 0.003 |
| non-TNBC | 17 (81.0%) | 65 (65.0%) | 56 (78.9%) | 26 (52.0%) | ||
| HER2 status | ||||||
| negative | 16 (76.2%) | 70 (70.0%) | 47 (66.2%) | 39 (78.0%) | 0.222 | |
| positive | 5 (23.8%) | 30 (30.0%) | 0.792 | 24 (33.8%) | 11 (22.0%) | |
| Age at operation | ||||||
| ≤ 56 | 12 (57.1%) | 45 (45.0%) | 0.344 | 34 (47.9%) | 23 (46.0%) | 0.855 |
| > 56 | 9 (42.9%) | 55 (55.0%) | 37 (52.1%) | 27 (54.0%) | ||
| Menopause | ||||||
| Negative | 10 (47.6%) | 38 (38.0%) | 0.466 | 28 (39.4%) | 20 (40.0%) | 0.950 |
| Positive | 11 (52.4%) | 62 (62.0%) | 43 (60.6%) | 30 (60.0%) | ||
| Tumor size | ||||||
| ≤ 2 cm | 2 (9.5%) | 15 (15.0%) | 0.734 | 9 (12.7%) | 8 (16.0%) | 0.607 |
| > 2 cm | 19 (90.5%) | 85 (85.0%) | 62 (87.3%) | 42 (84.0%) | ||
| Lymph node status | ||||||
| Negative | 8 (38.1%) | 27 (27.0%) | 0.304 | 23 (32.4%) | 12 (24.0%) | 0.416 |
| Positive | 13 (61.9%) | 73 (73.0%) | 48 (67.6%) | 38 (76.0%) | ||
| Nuclear grade | ||||||
| 1, 2 | 16 (76.2%) | 78 (78.0%) | 0.857 | 54 (76.1%) | 40 (80.0%) | 0.663 |
| 3 | 5 (23.8%) | 22 (22.0%) | 17 (23.9%) | 10 (20.0%) | ||
| Ki67 | ||||||
| ≤ 14% | 6 (28.6%) | 45 (45.0%) | 0.225 | 30 (42.3%) | 21 (42.0%) | 0.978 |
| > 14% | 15 (71.4%) | 55 (55.0%) | 41 (57.7%) | 29 (58.0%) | ||
| Pathological response | ||||||
| pCR | 7 (33.3%) | 41 (41.0%) | 0.627 | 39 (54.9%) | 34 (68.0%) | 0.187 |
| non-pCR | 14 (66.7%) | 59 (59.0%) | 32 (45.1%) | 16 (32.0%) | ||
| Plakoglobin | ||||||
| Low | Not | Not | 54 (76.1%) | 46 (92.0%) | 0.023 | |
| High | determined | determined | 17 (23.9%) | 4 (8.0%) | ||
| E-cadherin | ||||||
| Negative | 4 (19.0%) | 46 (46.0%) | 0.023 | Not | Not | |
| Positive | 17 (81.0%) | 54 (54.0%) | determined | determined | ||
