Fig. 1
![Fig. 1](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs40364-017-0098-3/MediaObjects/40364_2017_98_Fig1_HTML.gif)
BRAF intronic splice and branch point sequences in melanomas expressing the BRAF exon 4–8∆ transcript. a Schematic diagram of the BRAF gene, showing exons (numbered boxes) and introns (black bars) and the alternate splicing event leading to the BRAF exon 4–8∆ transcript. b Sanger sequencing traces showing the sequence encompassing the junction between BRAF intron 8 and exon 9 in BRAF inhibitor resistant melanomas (Progs) expressing the BRAF exon 4–8∆ transcripts and derived from patient 7, 10 and 28. The branch point motifs, including the −51 nucleotide associated with BRAF exon 4–8∆ splicing, and splice sites are boxed