Skip to main content

Table 1 Summary of detection techniques for bone biomarkers

From: Bone biomarker for the clinical assessment of osteoporosis: recent developments and future perspectives

Biomarker

Method

Concentration

Reference

Total ALP

standard Technicon Auto-analyzer

113 U/L

[12]

Total ALP

Roche COBAS Integra 800

>129 U/L

[13]

Total ALP

Olympus AU 5200 analyzer

64.8–79.7 U/L

[14]

BALP

enzyme immunoassay

24.9–19.7 U/L

[24]

BALP

enzyme immunoassay

66.4 ± 8.7 U/L

[25]

OC

antibody immunoassay

4.1 ± 0.5 ng/mL

[27]

OC

ELISA

16.16 ± 4.5 ng/mL

[28]

P1NP

Elecsys 2010 automated analyzer

54.1 μg/L

[29]

P1CP

radioimmunoassay

97–116 ng/mL

[32]

HYP

Bergman and Loxley method

34.7 mg/g creatinine

[35]

GHYL

HPLC

1.35 ± 0.82 mmol/mol

[39]

GHYL

HPLC

1.93–6.07 μmol/L

[40]

DPD

HPLC

11.3–22.3 nmol/L

[40]

DPD

chemiluminescence immunoassay

4.7 nmol/L

[42]

DPD

enzyme immunoassay

4.4 nmol/L

[42]

PYD

HPLC

28.8 μmol/mol creatinine

[45]

BSP

radioimmunoassay

12.1 ± 5.0 μg/L

[48]

BSP

radioimmunoassay

8.0 μg/L

[49]

OP

ELISA

20.75 ± 5.36 ng/mL

[51]

TRAP 5b

enzyme immunoassay

4.0 U/L

[54]

TRAP 5b

enzyme immunoassay

3.40 ± 0.87 U/L

[55]

CTX-1

ELISA

0.17–0.30 ng/ml

[56]

NTX-1

ELISA

37 ± 15 nmol BCE/mmol Cr

[57]

CTSK

ELISA

10.17 pmol/L

[59]

RANKL

ELISA

0.08 pmol/L

[61]

OPG

ELISA

1.8 pmol/L

[61]

DDK-1

ELISA

34.3 pmol/L

[65]

Sclerostin

ELISA

29.5 pmol/L

[65]