TY - JOUR AU - Boman, Karolina AU - Andersson, Gustav AU - Wennersten, Christoffer AU - Nodin, Björn AU - Ahlgren, Göran AU - Jirström, Karin PY - 2017 DA - 2017/03/14 TI - Podocalyxin-like and RNA-binding motif protein 3 are prognostic biomarkers in urothelial bladder cancer: a validatory study JO - Biomarker Research SP - 10 VL - 5 IS - 1 AB - Urothelial bladder cancer (UBC) is a disease that often is discovered when the tumour is non-muscle invasive, i.e. in Ta or T1 stage. Some patients will progress into muscle-invasive disease, a potentially deadly condition. Although there are some prognostic models, the need for prognostic and predictive biomarkers is considerate and urgent. Membranous expression of podocalyxin-like protein 1 (PODXL) and low expression of the RNA-binding motif 3 (RBM3) has previously been shown to be associated with an aggressive tumour phenotype and poor prognosis in several forms of cancer, including UBC. In this study, we sought to validate the prognostic impact of PODXL and RBM3 in an independent cohort of UBC. SN - 2050-7771 UR - https://doi.org/10.1186/s40364-017-0090-y DO - 10.1186/s40364-017-0090-y ID - Boman2017 ER -