Unadjusted effects on differences | Adjusted effects on differences | ||||||||
---|---|---|---|---|---|---|---|---|---|
miRNA1 | miRNA2 | HR (CI) | P | N | miRNA1 | miRNA2 | HR (CI) | P | N |
PDAC + AAC | |||||||||
miR-148a | miR-212-3p | 1.20 (1.09–1.33) | 0.0002 | 155 | miR-34a-5p | miR-148a | 0.82 (0.73–0.92) | 0.0011 | 144 |
miR-205-5p | miR-769-5p | 0.90 (0.85–0.95) | 0.0003 | 129 | miR-205-5p | miR-769-5p | 0.91 (0.85–0.96) | 0.0015 | 119 |
miR-148a | miR-205-5p | 1.08 (1.04–1.13) | 0.0004 | 130 | miR-146a-5p | miR-212-3p | 1.33 (1.11–1.60) | 0.0017 | 145 |
miR-34a-5p | miR-148a | 0.83 (0.75–0.92) | 0.0009 | 155 | miR-34a-5p | miR-187 | 0.67 (0.52–0.88) | 0.0038 | 44 |
miR-34a-5p | miR-187 | 0.64 (0.50–0.83) | 0.0009 | 47 | miR-148a | miR-205-5p | 1.07 (1.02–1.12) | 0.004 | 120 |
miR-146a-5p | miR-212-3p | 1.32 (1.12–1.57) | 0.0013 | 156 | miR-29a-5p | miR-205-5p | 1.08 (1.03–1.15) | 0.0046 | 119 |
miR-187 | miR-212-3p | 1.55 (1.18–2.04) | 0.0016 | 47 | miR-125a-3p | miR-769-5p | 0.81 (0.69–0.94) | 0.0071 | 140 |
miR-34a-5p | miR-769-5p | 0.74 (0.62–0.89) | 0.0017 | 154 | miR-187 | miR-212-3p | 1.47 (1.11–1.96) | 0.0078 | 44 |
miR-212-3p | miR-769-5p | 0.81 (0.70–0.92) | 0.0020 | 154 | let-7 g | miR-187 | 0.74 (0.59–0.93) | 0.0085 | 44 |
miR-205-5p | miR-625-5p | 0.91 (0.86–0.97) | 0.0023 | 72 | miR-146a-5p | miR-205-5p | 1.08 (1.02–1.14) | 0.0097 | 120 |
miR-205-5p | miR-450b-5p | 0.91 (0.86–0.97) | 0.0031 | 94 | miR-205-5p | miR-222-5p | 0.93 (0.87–0.99) | 0.0152 | 117 |
miR-146a-5p | miR-205-5p | 1.08 (1.03–1.14) | 0.0033 | 130 | miR-29a-5p | miR-769-5p | 0.81 (0.68–0.96) | 0.0171 | 143 |
miR-205-5p | miR-222-5p | 0.92 (0.86–0.97) | 0.0034 | 127 | let-7 g | miR-205-5p | 1.07 (1.01–1.13) | 0.018 | 120 |
let-7 g | miR-205-5p | 1.08 (1.02–1.14) | 0.0048 | 130 | miR-29a-5p | miR-194-3p | 0.68 (0.50–0.94) | 0.0188 | 46 |
miR-194-3p | miR-205-5p | 1.26 (1.07–1.48) | 0.0062 | 36 | miR-125a-3p | miR-187 | 0.76 (0.61–0.96) | 0.0188 | 43 |
miR-29a-5p | miR-205-5p | 1.07 (1.02–1.13) | 0.0072 | 129 | let-7 g | miR-212-3p | 1.14 (1.02–1.28) | 0.0233 | 144 |
miR-125a-3p | miR-205-5p | 1.08 (1.02–1.15) | 0.0074 | 128 | miR-125a-3p | miR-205-5p | 1.07 (1.01–1.14) | 0.0236 | 118 |
let-7 g | miR-187 | 0.82 (0.70–0.95) | 0.0093 | 47 | miR-205-5p | miR-450b-5p | 0.93 (0.87–0.99) | 0.024 | 85 |
miR-34a-5p | miR-205-5p | 1.07 (1.02–1.13) | 0.0125 | 130 | miR-34a-5p | miR-194-3p | 0.64 (0.43–0.94) | 0.0262 | 45 |
miR-125a-3p | miR-148a | 0.90 (0.83–0.98) | 0.0139 | 152 | miR-194-3p | miR-212-3p | 1.39 (1.04–1.85) | 0.0273 | 45 |
miR-125a-3p | miR-769-5p | 0.84 (0.73–0.97) | 0.0146 | 151 | miR-212-3p | miR-625-5p | 0.86 (0.75–0.98) | 0.0298 | 74 |
miR-125a-3p | miR-187 | 0.80 (0.66–0.96) | 0.0155 | 46 | miR-34a-5p | miR-205-5p | 1.07 (1.01–1.13) | 0.0307 | 120 |
miR-212-3p | miR-625-5p | 0.87 (0.77–0.98) | 0.0194 | 79 | miR-194-3p | miR-205-5p | 1.21 (1.02–1.45) | 0.0326 | 33 |
let-7 g | miR-212-3p | 1.12 (1.01–1.25) | 0.0332 | 155 | miR-625-5p | miR-944 | 1.51 (1.03–2.22) | 0.0339 | 20 |
miR-187 | miR-194-3p | 1.41 (1.02–1.96) | 0.0366 | 21 | miR-125a-3p | miR-148a | 0.91 (0.84–1.00) | 0.0383 | 141 |
miR-205-5p | miR-212-3p | 0.95 (0.90–1.00) | 0.0410 | 130 | miR-146a-5p | miR-769-5p | 0.84 (0.71–1.00) | 0.0394 | 144 |
miR-34a-5p | miR-625-5p | 0.88 (0.78–1.00) | 0.0443 | 79 | miR-34a-5p | miR-625-5p | 0.87 (0.75–1.00) | 0.0478 | 74 |
miR-146a-5p | miR-187 | 0.79 (0.63–1.00) | 0.0452 | 47 |  |  |  |  |  |
miR-187 | miR-205-5p | 1.12 (1.00–1.26) | 0.0468 | 38 |  |  |  |  |  |
miR-34a-5p | miR-146a-5p | 0.83 (0.68–1.00) | 0.0488 | 156 |  |  |  |  |  |
PDAC | Â | ||||||||
miR-148a | miR-212-3p | 1.18 (1.04–1.33) | 0.0077 | 103 | miR-34a-5p | miR-769-5p | 0.63 (0.47–0.84) | 0.002 | 92 |
miR-34a-5p | miR-148a | 0.86 (0.76–0.97) | 0.0156 | 103 | miR-29a-5p | miR-187 | 1.99 (1.20–3.29) | 0.0072 | 20 |
miR-34a-5p | miR-769-5p | 0.75 (0.59–0.96) | 0.0199 | 102 | miR-187 | miR-769-5p | 0.54 (0.33–0.87) | 0.0111 | 20 |
miR-146a-5p | miR-212-3p | 1.26 (1.01–1.56) | 0.0371 | 103 | miR-187 | miR-205-5p | 0.72 (0.56–0.94) | 0.0138 | 19 |
miR-34a-5p | miR-146a-5p | 0.74 (0.56–0.99) | 0.0427 | 103 | miR-212-3p | miR-769-5p | 0.75 (0.60–0.95) | 0.0153 | 92 |
 |  |  |  |  | miR-148a | miR-212-3p | 1.18 (1.03–1.34) | 0.016 | 93 |
 |  |  |  |  | miR-450b-5p | miR-944 | 1.56 (1.06–2.30) | 0.0243 | 24 |
 |  |  |  |  | miR-34a-5p | miR-148a | 0.86 (0.75–0.99) | 0.0341 | 93 |
 |  |  |  |  | miR-146a-5p | miR-212-3p | 1.29 (1.02–1.63) | 0.0343 | 93 |
 |  |  |  |  | miR-148a | miR-431-5p | 1.32 (1.02–1.72) | 0.0364 | 34 |
 |  |  |  |  | miR-146a-5p | miR-187 | 1.57 (1.01–2.44) | 0.0438 | 20 |
 |  |  |  |  | miR-222-5p | miR-769-5p | 0.84 (0.70–1.00) | 0.0491 | 92 |
A-AC | Â | ||||||||
miR-205-5p | miR-769-5p | 0.71 (0.60–0.84) | <0.0001 | 36 | miR-34a-5p | miR-769-5p | 0.51 (0.32–0.81) | 0.0043 | 51 |
miR-34a-5p | miR-187 | 0.44 (0.27–0.72) | 0.0011 | 24 | miR-125a-3p | miR-187 | 0.37 (0.18–0.75) | 0.0055 | 23 |
miR-148a | miR-205-5p | 1.25 (1.09–1.44) | 0.0018 | 37 | miR-34a-5p | miR-187 | 0.48 (0.28–0.82) | 0.0067 | 24 |
miR-125a-3p | miR-187 | 0.69 (0.54–0.88) | 0.0032 | 23 | miR-148a | miR-187 | 0.59 (0.40–0.87) | 0.0074 | 24 |
miR-187 | miR-205-5p | 1.35 (1.10–1.66) | 0.0041 | 17 | miR-29a-5p | miR-769-5p | 0.65 (0.48–0.89) | 0.0077 | 52 |
miR-187 | miR-212-3p | 2.22 (1.29–3.82) | 0.0042 | 24 | miR-222-5p | miR-450b-5p | 2.12 (1.18–3.81) | 0.0123 | 25 |
miR-205-5p | miR-450b-5p | 0.73 (0.59–0.91) | 0.0045 | 22 | miR-187 | miR-769-5p | 2.09 (1.16–3.78) | 0.0148 | 24 |
let-7 g | miR-205-5p | 1.28 (1.07–1.52) | 0.006 | 37 | miR-29a-5p | miR-187 | 0.62 (0.42–0.91) | 0.0154 | 24 |
miR-146a-5p | miR-205-5p | 1.19 (1.05–1.34) | 0.0065 | 37 | miR-187 | miR-212-3p | 2.23 (1.16–4.30) | 0.016 | 24 |
let-7 g | miR-769-5p | 0.74 (0.59–0.93) | 0.0083 | 52 | miR-146a-5p | miR-187 | 0.54 (0.33–0.90) | 0.0175 | 24 |
miR-34a-5p | miR-769-5p | 0.66 (0.48–0.91) | 0.0122 | 52 | miR-148a | miR-450b-5p | 2.12 (1.14–3.96) | 0.0181 | 26 |
miR-34a-5p | miR-205-5p | 1.22 (1.04–1.43) | 0.0126 | 37 | miR-450b-5p | miR-769-5p | 0.31 (0.12–0.84) | 0.0214 | 26 |
let-7 g | miR-187 | 0.77 (0.62–0.95) | 0.017 | 24 | miR-34a-5p | miR-625-5p | 0.71 (0.52–0.96) | 0.0267 | 30 |
let-7 g | miR-625-5p | 0.74 (0.58–0.95) | 0.0175 | 31 | miR-125a-3p | miR-769-5p | 0.75 (0.58–0.97) | 0.0283 | 49 |
miR-125a-3p | miR-205-5p | 1.21 (1.03–1.43) | 0.0227 | 36 | miR-29a-5p | miR-625-5p | 0.74 (0.56–0.99) | 0.0408 | 30 |
let-7 g | miR-222-5p | 0.80 (0.67–0.97) | 0.0242 | 50 | miR-205-5p | miR-222-5p | 0.81 (0.66–0.99) | 0.0436 | 33 |
miR-29a-5p | miR-187 | 0.74 (0.56–0.97) | 0.0272 | 24 |  |  |  |  |  |
miR-205-5p | miR-212-3p | 0.86 (0.75–0.98) | 0.0289 | 37 |  |  |  |  |  |
miR-146a-5p | miR-187 | 0.67 (0.46–0.96) | 0.0308 | 24 |  |  |  |  |  |
miR-187 | miR-769-5p | 1.47 (1.02–2.11) | 0.0367 | 24 |  |  |  |  |  |
miR-450b-5p | miR-769-5p | 0.59 (0.35–1.00) | 0.0489 | 27 |  |  |  |  |  |