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Table 4 Prognostic miRNAs in patients with PC + A-AC, PC and A-AC

From: Tissue MicroRNA profiles as diagnostic and prognostic biomarkers in patients with resectable pancreatic ductal adenocarcinoma and periampullary cancers

PDAC and A-AC
CT-expression (per IQR increase)
  Unadjusted Adjusted
miRNA HR (CI) P N HR (CI) P N
miR-29a-5p 0.87 (0.76–0.99) 0.0302 156 0.85 (0.74–0.98) 0.0212 145
miR-34a-5p 0.66 (0.54–0.81) <0.0001 156 0.64 (0.52–0.79) <0.0001 145
miR-125a-3p 0.83 (0.73–0.95) 0.0051 153 0.83 (0.72–0.95) 0.0077 142
miR-146a-5p 0.87 (0.76–0.99) 0.0296 157 0.85 (0.74–0.97) 0.0191 146
miR-205-5p 0.91 (0.86–0.96) 4e-04 130 0.92 (0.87–0.97) 0.0037 120
miR-212-3p 0.81 (0.72–0.91) 4e-04 156 0.80 (0.71–0.91) 4e-04 145
Under median vs. over median
  Unadjusted Adjusted
miRNA HR (CI) P N HR (CI) P N
let-7 g NS    0.62 (0.41–0.93) 0.0220 145
miR-29a-5p NS    0.64 (0.42–0.96) 0.0314 145
miR-34a-5p 0.46 (0.31–0.67) <0.0001 156 0.47 (0.31–0.71) 0.0003 145
miR-205-5p 0.37 (0.25–0.57) <0.0001 130 0.44 (0.28–0.69) 0.0003 120
miR-212-3p 0.51 (0.35–0.74) 5e-04 156 0.53 (0.35–0.79) 0.0021 145
miR-222-5p 0.68 (0.47–1.00) 0.0495 152 NS   
PDAC
CT-expression (per IQR increase)
  Unadjusted Adjusted
miRNA HR (CI) P N HR (CI) P N
miR-34a-5p 0.72 (0.56–0.93) 0.0104 103 0.70 (0.52–0.93) 0.0144 93
miR-212-3p 0.83 (0.71–0.99) 0.0328 103 0.82 (0.68–0.99) 0.0350 93
Under median vs. over median
  Unadjusted Adjusted
miRNA HR (CI) P N HR (CI) P N
miR-34a-5p 0.49 (0.31–0.77) 0.0020 103 0.53 (0.32–0.89) 0.0151 93
miR-212-3p 0.64 (0.41–0.98) 0.0417 103 0.59 (0.36–0.97) 0.0358 93
A-AC
CT-expression (per IQR increase)
  Unadjusted Adjusted
miRNA HR (CI) P N HR (CI) P N
let-7 g 0.74 (0.58–0.93) 0.0100 53 NS   
miR-34a-5p 0.66 (0.46–0.94) 0.0218 53 0.58 (0.38–0.89) 0.0121 52
miR-187 1.51 (1.01–2.24) 0.0439 24 2.34 (1.22–4.48) 0.0104 24
miR-205-5p 0.73 (0.63–0.86) 0.0001 37 NS   
miR-450b-5p NS    0.48 (0.23–0.99) 0.0458 26
Under median vs. over median
  Unadjusted Adjusted
miRNA HR (CI) P N HR (CI) P N
miR-34a-5p 0.40 (0.19–0.86) 0.0183 53 0.36 (0.16–0.85) 0.0195 52
  1. NS Not significant