Tissue MicroRNA profiles as diagnostic and prognostic biomarkers in patients with resectable pancreatic ductal adenocarcinoma and periampullary cancers

Calatayud, Dan; Dehlendorff, Christian; Boisen, Mogens K.; Hasselby, Jane Preuss; Schultz, Nicolai Aagaard; Werner, Jens; Immervoll, Heike; Molven, Anders; Hansen, Carsten Palnæs; Johansen, Julia S.

doi:10.1186/s40364-017-0087-6

Table 4 Prognostic miRNAs in patients with PC + A-AC, PC and A-AC

From: Tissue MicroRNA profiles as diagnostic and prognostic biomarkers in patients with resectable pancreatic ductal adenocarcinoma and periampullary cancers

PDAC and A-AC
CT-expression (per IQR increase)
	Unadjusted			Adjusted
miRNA	HR (CI)	P	N	HR (CI)		P	N
miR-29a-5p	0.87 (0.76–0.99)	0.0302	156	0.85 (0.74–0.98)		0.0212	145
miR-34a-5p	0.66 (0.54–0.81)	<0.0001	156	0.64 (0.52–0.79)		<0.0001	145
miR-125a-3p	0.83 (0.73–0.95)	0.0051	153	0.83 (0.72–0.95)		0.0077	142
miR-146a-5p	0.87 (0.76–0.99)	0.0296	157	0.85 (0.74–0.97)		0.0191	146
miR-205-5p	0.91 (0.86–0.96)	4e-04	130	0.92 (0.87–0.97)		0.0037	120
miR-212-3p	0.81 (0.72–0.91)	4e-04	156	0.80 (0.71–0.91)		4e-04	145
Under median vs. over median
	Unadjusted			Adjusted
miRNA	HR (CI)	P	N	HR (CI)		P	N
let-7 g	NS			0.62 (0.41–0.93)		0.0220	145
miR-29a-5p	NS			0.64 (0.42–0.96)		0.0314	145
miR-34a-5p	0.46 (0.31–0.67)	<0.0001	156	0.47 (0.31–0.71)		0.0003	145
miR-205-5p	0.37 (0.25–0.57)	<0.0001	130	0.44 (0.28–0.69)		0.0003	120
miR-212-3p	0.51 (0.35–0.74)	5e-04	156	0.53 (0.35–0.79)		0.0021	145
miR-222-5p	0.68 (0.47–1.00)	0.0495	152	NS
PDAC
CT-expression (per IQR increase)
	Unadjusted			Adjusted
miRNA	HR (CI)	P	N	HR (CI)		P	N
miR-34a-5p	0.72 (0.56–0.93)	0.0104	103	0.70 (0.52–0.93)		0.0144	93
miR-212-3p	0.83 (0.71–0.99)	0.0328	103	0.82 (0.68–0.99)		0.0350	93
Under median vs. over median
	Unadjusted			Adjusted
miRNA	HR (CI)	P	N	HR	(CI)	P	N
miR-34a-5p	0.49 (0.31–0.77)	0.0020	103	0.53 (0.32–0.89)		0.0151	93
miR-212-3p	0.64 (0.41–0.98)	0.0417	103	0.59 (0.36–0.97)		0.0358	93
A-AC
CT-expression (per IQR increase)
	Unadjusted			Adjusted
miRNA	HR (CI)	P	N	HR (CI)		P	N
let-7 g	0.74 (0.58–0.93)	0.0100	53	NS
miR-34a-5p	0.66 (0.46–0.94)	0.0218	53	0.58 (0.38–0.89)		0.0121	52
miR-187	1.51 (1.01–2.24)	0.0439	24	2.34 (1.22–4.48)		0.0104	24
miR-205-5p	0.73 (0.63–0.86)	0.0001	37	NS
miR-450b-5p	NS			0.48 (0.23–0.99)		0.0458	26
Under median vs. over median
	Unadjusted			Adjusted
miRNA	HR (CI)	P	N	HR (CI)		P	N
miR-34a-5p	0.40 (0.19–0.86)	0.0183	53	0.36 (0.16–0.85)		0.0195	52

NS Not significant

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