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Table 2 Significantly deregulated microRNAs

From: Tissue MicroRNA profiles as diagnostic and prognostic biomarkers in patients with resectable pancreatic ductal adenocarcinoma and periampullary cancers

microRNA upregulated in PC compared to healthy subjects
miRNA OR (CI) p-value PC HS Missing
miR-21-5p 0.11 (0.03–0.25) 0.0000 134 13 53
miR-23a-3p 0.36 (0.13–0.67) 0.0100 156 5 39
miR-31-5p 0.38 (0.28–0.50) 0.0000 165 35 0
miR-34c-5p 0.17 (0.09–0.28) 0.0000 165 35 0
miR-93-3p 0.14 (0.06–0.26) 0.0000 165 34 1
miR-135b-3p 0.31 (0.20–0.44) 0.0000 165 30 5
miR-155-5p 0.11 (0.03–0.23) 0.0000 165 33 2
miR-196b-5p 0.14 (0.02–0.45) 0.0151 147 3 50
miR-203 0.37 (0.25–0.51) 0.0000 165 35 0
miR-205-5p 0.71 (0.59–0.82) 0.0000 148 21 31
miR-210 0.12 (0.05–0.22) 0.0000 165 34 1
miR-222-3p 0.06 (0.02–0.15) 0.0000 165 35 0
miR-451 0.14 (0.06–0.27) 0.0000 165 35 0
miR-622 0.57 (0.41–0.76) 0.0003 165 34 1
microRNA downregulated in PC compared to healthy subjects
miRNA OR (CI) p-value PC HS Missing
miR-122-5p 2.08 (1.40–3.51) 0.0014 30 18 152
miR-130b-3p 5.34 (3.17–9.98) 0.0000 165 35 0
miR-216b 6.30 (3.36–14.24) 0.0000 149 35 16
miR-217 2.94 (2.03–4.69) 0.0000 142 35 23
miR-375 26.10 (9.48–90.22) 0.0000 165 35 0
microRNA upregulated in PC compared to healthy subjects and chronic pancreatitis
miRNA OR (CI) p-value PC HS + CP Missing
miR-21-5p 0.24 (0.14–0.36) 0.0000 134 42 63
miR-23a-3p 0.54 (0.38–0.74) 0.0003 156 31 52
miR-31-5p 0.50 (0.41–0.59) 0.0000 165 74 0
miR-34c-5p 0.33 (0.25–0.43) 0.0000 165 74 0
miR-93-3p 0.27 (0.17–0.40 0.0000 165 73 1
miR-135b-3p 0.31 (0.22–0.41 0.0000 165 58 16
miR-155-5p 0.46 (0.37–0.56 0.0000 165 72 2
miR-186-5p 0.71 (0.55–0.89 0.0041 165 74 0
miR-196b-5p 0.53 (0.39–0.70 0.0000 147 20 72
miR-203 0.36 (0.26–0.46 0.0000 165 74 0
miR-205-5p 0.79 (0.71–0.88 0.0000 148 46 45
miR-210 0.27 (0.18–0.36 0.0000 165 73 1
miR-222-3p 0.23 (0.16–0.32 0.0000 165 74 0
miR-451 0.44 (0.35–0.54 0.0000 165 74 0
miR-492 0.46 (0.22–0.78 0.0097 57 4 178
miR-614 0.75 (0.57–0.94 0.0219 110 14 115
miR-622 0.52 (0.41–0.66 0.0000 165 72 2
microRNA downregulated in PC compared to healthy subjects and chronic pancreatitis
miRNA OR (CI) p-value PC HS + CP Missing
miR-122-5p 1.99 (1.46–2.98) 0.0001 30 40 169
miR-130b-3p 1.71 (1.33–2.23) 0.0001 165 74 0
miR-216b 1.55 (1.34–1.84) 0.0000 149 73 17
miR-217 1.46 (1.28–1.69) 0.0000 142 71 26
miR-375 2.22 (1.62–3.15) 0.0000 165 74 0