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Table 2 Significantly deregulated microRNAs

From: Tissue MicroRNA profiles as diagnostic and prognostic biomarkers in patients with resectable pancreatic ductal adenocarcinoma and periampullary cancers

microRNA upregulated in PC compared to healthy subjects

miRNA

OR (CI)

p-value

PC

HS

Missing

miR-21-5p

0.11 (0.03–0.25)

0.0000

134

13

53

miR-23a-3p

0.36 (0.13–0.67)

0.0100

156

5

39

miR-31-5p

0.38 (0.28–0.50)

0.0000

165

35

0

miR-34c-5p

0.17 (0.09–0.28)

0.0000

165

35

0

miR-93-3p

0.14 (0.06–0.26)

0.0000

165

34

1

miR-135b-3p

0.31 (0.20–0.44)

0.0000

165

30

5

miR-155-5p

0.11 (0.03–0.23)

0.0000

165

33

2

miR-196b-5p

0.14 (0.02–0.45)

0.0151

147

3

50

miR-203

0.37 (0.25–0.51)

0.0000

165

35

0

miR-205-5p

0.71 (0.59–0.82)

0.0000

148

21

31

miR-210

0.12 (0.05–0.22)

0.0000

165

34

1

miR-222-3p

0.06 (0.02–0.15)

0.0000

165

35

0

miR-451

0.14 (0.06–0.27)

0.0000

165

35

0

miR-622

0.57 (0.41–0.76)

0.0003

165

34

1

microRNA downregulated in PC compared to healthy subjects

miRNA

OR (CI)

p-value

PC

HS

Missing

miR-122-5p

2.08 (1.40–3.51)

0.0014

30

18

152

miR-130b-3p

5.34 (3.17–9.98)

0.0000

165

35

0

miR-216b

6.30 (3.36–14.24)

0.0000

149

35

16

miR-217

2.94 (2.03–4.69)

0.0000

142

35

23

miR-375

26.10 (9.48–90.22)

0.0000

165

35

0

microRNA upregulated in PC compared to healthy subjects and chronic pancreatitis

miRNA

OR (CI)

p-value

PC

HS + CP

Missing

miR-21-5p

0.24 (0.14–0.36)

0.0000

134

42

63

miR-23a-3p

0.54 (0.38–0.74)

0.0003

156

31

52

miR-31-5p

0.50 (0.41–0.59)

0.0000

165

74

0

miR-34c-5p

0.33 (0.25–0.43)

0.0000

165

74

0

miR-93-3p

0.27 (0.17–0.40

0.0000

165

73

1

miR-135b-3p

0.31 (0.22–0.41

0.0000

165

58

16

miR-155-5p

0.46 (0.37–0.56

0.0000

165

72

2

miR-186-5p

0.71 (0.55–0.89

0.0041

165

74

0

miR-196b-5p

0.53 (0.39–0.70

0.0000

147

20

72

miR-203

0.36 (0.26–0.46

0.0000

165

74

0

miR-205-5p

0.79 (0.71–0.88

0.0000

148

46

45

miR-210

0.27 (0.18–0.36

0.0000

165

73

1

miR-222-3p

0.23 (0.16–0.32

0.0000

165

74

0

miR-451

0.44 (0.35–0.54

0.0000

165

74

0

miR-492

0.46 (0.22–0.78

0.0097

57

4

178

miR-614

0.75 (0.57–0.94

0.0219

110

14

115

miR-622

0.52 (0.41–0.66

0.0000

165

72

2

microRNA downregulated in PC compared to healthy subjects and chronic pancreatitis

miRNA

OR (CI)

p-value

PC

HS + CP

Missing

miR-122-5p

1.99 (1.46–2.98)

0.0001

30

40

169

miR-130b-3p

1.71 (1.33–2.23)

0.0001

165

74

0

miR-216b

1.55 (1.34–1.84)

0.0000

149

73

17

miR-217

1.46 (1.28–1.69)

0.0000

142

71

26

miR-375

2.22 (1.62–3.15)

0.0000

165

74

0

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