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Table 1 Emerging evidence of DNMTs in malignant transformation

From: DNA methyltransferases and their roles in tumorigenesis

Tumor type DNMT subtype Model studied Alteration Reference
AML DNMT3A
DNMT3A
DNMT3A
DNMT3B
DNMTs
Patients
Mouse tumor model
Mouse tumor model
Mouse tumor model
Patients
Mutation
Mutation
Deletion
Deletion
Overexpression
[15, 16, 34]
[72]
[3943]
[46]
[74]
MDS DNMT3A Patients Mutation [35]
CMML DNMT3A Mouse model Mutation [37]
CML DNMTs Patients Overexpression [74]
ALL DNMT3A Patients Mutation [36]
Lymphoma DNMT1
DNMT3A
DNMT3B
Mouse tumor model
Mouse model
Mouse tumor model
Deletion
Deletion
Deletion
[47]
[44]
[75]
Breast DNMT1
DNMT1
DNMT3B
Mouse tumor model
Patients
Patients
Deletion
Overexpression
Overexpression
[76]
[77]
[26]
Lung DNMT3A Mouse tumor model Deletion [45]
Colon DNMT1
DNMT3B
DNMT3B
Patients
Patients
Mouse tumor model
Mutation
Overexpression
Overexpression
[33]
[29, 30]
[27, 28]
Liver DNMT1
DNMT3A
Patients
Patients
Overexpression
Overexpression
[24]
[25]
Melanoma DNMT3A Mouse tumor model Overexpression [78]
Pancreas DNMT1 Patients Overexpression [23]
Prostate DNMT3B Patients Overexpression [31]
Esophagus DNMT1 Patients Overexpression [22]