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Table 1 Emerging evidence of DNMTs in malignant transformation

From: DNA methyltransferases and their roles in tumorigenesis

Tumor type

DNMT subtype

Model studied

Alteration

Reference

AML

DNMT3A

DNMT3A

DNMT3A

DNMT3B

DNMTs

Patients

Mouse tumor model

Mouse tumor model

Mouse tumor model

Patients

Mutation

Mutation

Deletion

Deletion

Overexpression

[15, 16, 34]

[72]

[3943]

[46]

[74]

MDS

DNMT3A

Patients

Mutation

[35]

CMML

DNMT3A

Mouse model

Mutation

[37]

CML

DNMTs

Patients

Overexpression

[74]

ALL

DNMT3A

Patients

Mutation

[36]

Lymphoma

DNMT1

DNMT3A

DNMT3B

Mouse tumor model

Mouse model

Mouse tumor model

Deletion

Deletion

Deletion

[47]

[44]

[75]

Breast

DNMT1

DNMT1

DNMT3B

Mouse tumor model

Patients

Patients

Deletion

Overexpression

Overexpression

[76]

[77]

[26]

Lung

DNMT3A

Mouse tumor model

Deletion

[45]

Colon

DNMT1

DNMT3B

DNMT3B

Patients

Patients

Mouse tumor model

Mutation

Overexpression

Overexpression

[33]

[29, 30]

[27, 28]

Liver

DNMT1

DNMT3A

Patients

Patients

Overexpression

Overexpression

[24]

[25]

Melanoma

DNMT3A

Mouse tumor model

Overexpression

[78]

Pancreas

DNMT1

Patients

Overexpression

[23]

Prostate

DNMT3B

Patients

Overexpression

[31]

Esophagus

DNMT1

Patients

Overexpression

[22]