Plasma microRNA biomarker detection for mild cognitive impairment using differential correlation analysis

Biomarker Research

Table 3 Summary of the 20 pairs of miRNAs detected by differential correlation between Normal and MCI. The miRNA pairs are ranked by the difference of the correlation coefficients. The mean AUC value for the 20 miRNA pairs is 0.800 ± 0.051

Rank	Pair of miRNAs		\|r ₁−r ₂\|	log10	AUC	Correlation	Coefficients
				p-value		Normal (r ₁)	MCI (r ₂)
1	hsa-miR-191	hsa-miR-590-5p	0.963	-3.76	0.880	0.764	-0.200
2	hsa-miR-125b	hsa-miR-18a	0.930	-3.55	0.733	-0.218	0.712
3	hsa-miR-140-3p	hsa-miR-191	0.921	-2.85	0.800	0.540	-0.381
4	hsa-miR-103	hsa-miR-19b	0.917	-3.56	0.797	0.776	-0.141
5	hsa-miR-192	hsa-miR-197	0.912	-3.61	0.867	-0.281	0.631
6	hsa-miR-191	hsa-miR-19b	0.911	-4.10	0.854	0.826	-0.085
7	hsa-miR-152	hsa-miR-191	0.892	-3.42	0.863	0.772	-0.121
8	hsa-miR-103	hsa-miR-590-5p	0.888	-3.24	0.749	0.614	-0.275
9	hsa-miR-191	hsa-miR-320a	0.873	-3.38	0.872	0.691	-0.182
10	hsa-miR-125b	hsa-miR-20a	0.871	-3.80	0.801	-0.090	0.781
11	hsa-miR-106a	hsa-miR-125b	0.869	-3.94	0.785	-0.083	0.786
12	hsa-miR-101	hsa-miR-103	0.865	-3.65	0.768	0.805	-0.060
13	hsa-miR-125b	hsa-miR-24	0.840	-3.42	0.801	-0.073	0.768
14	hsa-miR-101	hsa-miR-191	0.831	-3.96	0.871	0.822	-0.009
15	hsa-miR-103	hsa-miR-222	0.828	-3.24	0.745	0.622	-0.207
16	hsa-miR-197	hsa-miR-378	0.820	-2.78	0.810	-0.234	0.586
17	hsa-miR-103	hsa-miR-223	0.815	-3.79	0.786	0.840	0.025
18	hsa-miR-125b	hsa-miR-223	0.815	-3.49	0.765	-0.015	0.800
19	hsa-let-7b	hsa-miR-125b	0.811	-3.75	0.718	-0.056	0.755
20	hsa-miR-125b	hsa-miR-484	0.801	-3.52	0.739	-0.078	0.723

ISSN: 2050-7771