Table 1 Assay parameters of imaging modalities and classical biomarkers used in detection of pancreatic cancer
From: Advance in microRNA as a potential biomarker for early detection of pancreatic cancer
Item | AUC | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Accuracy (%) | Reference |
|---|---|---|---|---|---|---|---|
CT | 0.832 | 92 | - | 80 | 67 | - | [19] |
MRI | 0.92 | 100 | - | 90 | 100 | - | [19] |
EUS-FNA | - | 82.1 | 100 | 100 | 79.2 | 89.4 | [20] |
MRCP | - | - | - | 85 | - | 80 | [21] |
ERCP | - | - | - | 88 | - | 85 | [21] |
MRI+ERCP | - | - | - | 91 | - | 88 | [21] |
18F-FDGPE/CT | 0.759 | 67.50 | 72.73 | 94.74 | 23.53 | 68.13 | [22] |
CA19-9 | 0.857 | 75.00 | 81.82 | 96.77 | 31.03 | 75.82 | [22] |
18F-FDGPE/CT + CA19-9 | 0.940 | 96.25 | 63.64 | 95.06 | 70.00 | 92.31 | [22] |
CA125 | 0.810 | 78.68 | 71.05 | 79.63 | 51.92 | - | [23] |
CEA | 0.670 | 63.24 | 63.16 | 75.44 | 48.98 | - | |
CA50 | 0.630 | 52.21 | 78.95 | 81.61 | 48.00 | - | |
CA724 | 0.670 | 65.44 | 68.42 | 78.76 | 52.53 | - | |
CA242 | 0.640 | 64.71 | 60.53 | 74.58 | 48.94 | - | |
AFP | 0.490 | 43.38 | 61.84 | 67.05 | 37.90 | - |