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Table 1 Clinical course

From: Pediatric chronic myeloid leukemia with inv(3)(q21q26.2) and T lymphoblastic transformation: a case report

Day of TKI treatment

Clinical event

qPCR BCR/ABL, Blood (IS units)

qPCR BCR/ABL, Marrow (IS units)

T lymphoblasts, Marrow

−1

CML diagnosis confirmed

44 %

 

9 %

1

Started imatinib 500 mg daily

   

22

 

58 %

  

25

  

65 %

1 %

29

 

69 %

  

34

 

50 %

  

41

 

67 %

  

49

Started dasatinib 100 mg daily

56 %

  

54

 

52 %

52 %

0.02 %

64

 

28 %

  

68

 

22 %

  

92

 

4.3 %

  
  1. Timeline of clinical events, BCR-ABL1 transcript levels detected by qPCR in the blood and bone marrow, and percentage of T lymphoblasts in the bone marrow as measured by flow cytometry. Timeline is reported relative to day 1 of treatment with imatinib. TKI tyrosine kinase inhibitor, qPCR quantitative polymerase chain reaction, IS international standard units