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Table 4 GELA grading system for post-treatment evaluation of gastric MALT lymphoma [35]

From: Gastric mucosa-associated lymphoid tissue lymphoma and Helicobacter pylori infection: a review of current diagnosis and management

GELA category Histological features Clinical category
Complete histological response (CR) Total disappearance of lymphoid infiltrate with only scattered small lymphocytes and plasma cells. Regressive stromal changes with fibrosis and separation of glands can be observed. Complete remission
Probable minimal residual disease (pMRD) Small lymphoid aggregates present, stromal regressive changes are usually present. Complete remission
Responding residual disease (rRD) Overt residual lymphoma with a nodular or diffuse infiltrate of neoplastic B-cells but with clear evidence of regressive stromal changes characterized by fine fibrosis and an “empty lamina propria.” Partial remission
No change (NC) Persistence of overt lymphoma identical to that observed at diagnosis with no morphological features to suggest response to treatment (such as stromal fibrosis). Stable or progressive disease
  1. GELA Groupe d’Etude des Lymphomes de l’Adult, MALT mucosa-associated lymphoid tissue