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Table 1 Wotherspoon scale of confidence of histological diagnosis of lymphoma [15]

From: Gastric mucosa-associated lymphoid tissue lymphoma and Helicobacter pylori infection: a review of current diagnosis and management

Grade Description Histological features
0 Normal Scattered plasma cells in the lamina propria. No lymphoid follicles.
1 Chronic active gastritis Small clusters of lymphocytes in the lamina propria. No lymphoid follicles. No LELs.
2 Chronic active gastritis with florid lymphoid follicle formation Prominent lymphoid follicles with surrounding mantle zone and plasma cells.
3 Suspicious lymphoid infiltrate, probably reactive Lymphoid follicles surrounded by CCL cells that infiltrate diffusely into the lamina propria and occasionally into the epithelium.
4 Suspicious lymphoid infiltrate, probably lymphoma Lymphoid follicles surrounded by CCL cells that infiltrate diffusely into the lamina propria and into the epithelium in small groups.
5 Low-grade B-cell lymphoma of MALT Presence of dense diffuse infiltrate of CCL cells in the lamina propria with prominent lymphoepithelial lesions.
  1. CCL cells centrocyte-like cells (or marginal zone cells), LEL lymphoepithelial lesion
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