TY - JOUR AU - Hofmann, Elisabeth AU - Seeboeck, Rita AU - Jacobi, Nico AU - Obrist, Peter AU - Huter, Samuel AU - Klein, Christian AU - Oender, Kamil AU - Wiesner, Christoph AU - Hundsberger, Harald AU - Eger, Andreas PY - 2016 DA - 2016/04/07 TI - The combinatorial approach of laser-captured microdissection and reverse transcription quantitative polymerase chain reaction accurately determines HER2 status in breast cancer JO - Biomarker Research SP - 8 VL - 4 IS - 1 AB - HER2 expression in breast cancer correlates with increased metastatic potential, higher tumor recurrence rates and improved response to targeted therapies. Fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) are two methods commonly used for the analysis of HER2 in the clinic. However, lack of standardization, technical variability in laboratory protocols and subjective interpretation are major problems associated with these testing procedures. SN - 2050-7771 UR - https://doi.org/10.1186/s40364-016-0062-7 DO - 10.1186/s40364-016-0062-7 ID - Hofmann2016 ER -