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Table 1 RECQ family member expression in hematological malignancies compared to that of their normal tissue counterparts using publicly available gene expression data, including the Oncomine Cancer Microarray and Genomicscape databases

From: RECQ helicases are deregulated in hematological malignancies in association with a prognostic value

 

Hematological Malignancies

Datasets

Gene overexpression compared to normal tissue counterpart

 

RECQ1

BLM

WRN

RECQ4

RECQ5

Myeloid Neoplasms

Acute Myeloid Leukemia

12

No

No

No

No

YES

B-cell neoplasms

Primary Effusion Lymphoma

8

No

No

YES

YES

No

Chronic Lymphocyte Leukemia

11

No

No

YES

No

No

Diffuse Large B-cell Lymphoma

8

No

No

No

YES

No

Burkitt's Lymphoma

8

No

No

No

YES

No

Mantle Cell Lymphoma

11

YES

No

No

No

No

Multiple Myeloma

1

YES

YES

YES

YES

No

T-cell neoplasms

Unspecified Peripheral T-cell Lymphoma

11

YES

No

No

No

No

Anaplastic Large Cell Lymphoma

11

YES

No

No

No

No

Angioimmunoblastic T-Cell Lymphoma

11

YES

No

No

No

No