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Table 4 Meta-analysis of the HIF1A 1790 G/A polymorphism association with cancer

From: A meta-analysis of hypoxia inducible factor 1-alpha (HIF1A) gene polymorphisms: association with cancers

 

AA vs. GG

GA vs. GG

AA vs. GA + GG

AA + GA vs. GG

A vs. G

 

Study number

Sample size

OR (95 % CI)

p value

OR (95 % CI)

p value

OR (95 % CI)

p value

OR (95 % CI)

p value

OR (95 % CI)

p value

Overall

19

10654

5.10 [3.12–8.33]

< 0.0001

1.74 [1.20–2.52]

0.0033

3.79 [2.34–6.15]

< 0.0001

1.82 [1.26–2.62]

0.0014

1.82 [1.31–2.52]

0.0003

Renal cancer

4

2503

5.11 [2.24–11.66]

0.0001

1.51 [0.45–5.05]

0.5038

3.05 [1.36–6.84]

0.0068

1.58 [0.49–5.03]

0.442

1.53 [0.60–3.92]

0.3747

Prostate cancer

3

4208

3.35 [0.14–82.30]

0.4597

1.41 [0.96–2.08]

0.0822

3.25 [0.13–79.90]

0.4707

1.41 [0.93–2.15]

0.1043

1.42 [0.93–2.17]

0.1093

Breast cancer

2

396

0.36 [0.01–8.95]

0.5332

0.35 [0.10–1.24]

0.1045

0.37 [0.02–9.29]

0.5484

0.32 [0.09–1.10]

0.0702

0.30 [0.09–1.00]

0.0495

Lung cancer

2

778

5.41 [2.74–10.69]

< 0.0001

1.76 [1.25–2.49]

0.0013

4.51 [2.31–8.81]

< 0.0001

2.20 [1.60–3.03]

< 0.0001

2.31 [1.77–3.02]

< 0.0001

OSCC

2

724

12.68 [1.43–112.64]

0.0227

4.69 [1.96–11.21]

0.0005

10.12 [1.14–89.72]

0.0376

5.17 [1.99–13.43]

0.0008

5.00 [2.10–11.97]

0.0003

Other cancers

6

2045

3.77 [0.15–93.07]

0.4171

1.96 [1.05–3.65]

0.0336

3.10 [0.13–76.51]

0.4887

1.96 [1.05–3.67]

0.0341

1.91 [1.06–3.44]

0.0306

Ethnicity

 Caucasian

8

2666

5.68 [2.57–12.58]

< 0.0001

1.43 [0.54–3.74]

0.4691

3.42 [1.57–7.45]

0.002

1.50 [0.58–3.85]

0.3987

1.52 [0.68–3.42]

0.3103

 Asian

10

4914

4.76 [2.55–8.91]

< 0.0001

1.94 [1.38–2.72]

0.0001

4.05 [2.1 –7.51]

< 0.0001

2.04 [1.44–2.87]

< 0.0001

2.03 [1.46–2.81]

< 0.0001