| AA vs. GG | GA vs. GG | AA vs. GA + GG | AA + GA vs. GG | A vs. G | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Study number | Sample size | OR (95 % CI) | p value | OR (95 % CI) | p value | OR (95 % CI) | p value | OR (95 % CI) | p value | OR (95 % CI) | p value |
Overall | 19 | 10654 | 5.10 [3.12–8.33] | < 0.0001 | 1.74 [1.20–2.52] | 0.0033 | 3.79 [2.34–6.15] | < 0.0001 | 1.82 [1.26–2.62] | 0.0014 | 1.82 [1.31–2.52] | 0.0003 |
Renal cancer | 4 | 2503 | 5.11 [2.24–11.66] | 0.0001 | 1.51 [0.45–5.05] | 0.5038 | 3.05 [1.36–6.84] | 0.0068 | 1.58 [0.49–5.03] | 0.442 | 1.53 [0.60–3.92] | 0.3747 |
Prostate cancer | 3 | 4208 | 3.35 [0.14–82.30] | 0.4597 | 1.41 [0.96–2.08] | 0.0822 | 3.25 [0.13–79.90] | 0.4707 | 1.41 [0.93–2.15] | 0.1043 | 1.42 [0.93–2.17] | 0.1093 |
Breast cancer | 2 | 396 | 0.36 [0.01–8.95] | 0.5332 | 0.35 [0.10–1.24] | 0.1045 | 0.37 [0.02–9.29] | 0.5484 | 0.32 [0.09–1.10] | 0.0702 | 0.30 [0.09–1.00] | 0.0495 |
Lung cancer | 2 | 778 | 5.41 [2.74–10.69] | < 0.0001 | 1.76 [1.25–2.49] | 0.0013 | 4.51 [2.31–8.81] | < 0.0001 | 2.20 [1.60–3.03] | < 0.0001 | 2.31 [1.77–3.02] | < 0.0001 |
OSCC | 2 | 724 | 12.68 [1.43–112.64] | 0.0227 | 4.69 [1.96–11.21] | 0.0005 | 10.12 [1.14–89.72] | 0.0376 | 5.17 [1.99–13.43] | 0.0008 | 5.00 [2.10–11.97] | 0.0003 |
Other cancers | 6 | 2045 | 3.77 [0.15–93.07] | 0.4171 | 1.96 [1.05–3.65] | 0.0336 | 3.10 [0.13–76.51] | 0.4887 | 1.96 [1.05–3.67] | 0.0341 | 1.91 [1.06–3.44] | 0.0306 |
Ethnicity | ||||||||||||
 Caucasian | 8 | 2666 | 5.68 [2.57–12.58] | < 0.0001 | 1.43 [0.54–3.74] | 0.4691 | 3.42 [1.57–7.45] | 0.002 | 1.50 [0.58–3.85] | 0.3987 | 1.52 [0.68–3.42] | 0.3103 |
 Asian | 10 | 4914 | 4.76 [2.55–8.91] | < 0.0001 | 1.94 [1.38–2.72] | 0.0001 | 4.05 [2.1 –7.51] | < 0.0001 | 2.04 [1.44–2.87] | < 0.0001 | 2.03 [1.46–2.81] | < 0.0001 |