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Table 4 Meta-analysis of the HIF1A 1790 G/A polymorphism association with cancer

From: A meta-analysis of hypoxia inducible factor 1-alpha (HIF1A) gene polymorphisms: association with cancers

  AA vs. GG GA vs. GG AA vs. GA + GG AA + GA vs. GG A vs. G
  Study number Sample size OR (95 % CI) p value OR (95 % CI) p value OR (95 % CI) p value OR (95 % CI) p value OR (95 % CI) p value
Overall 19 10654 5.10 [3.12–8.33] < 0.0001 1.74 [1.20–2.52] 0.0033 3.79 [2.34–6.15] < 0.0001 1.82 [1.26–2.62] 0.0014 1.82 [1.31–2.52] 0.0003
Renal cancer 4 2503 5.11 [2.24–11.66] 0.0001 1.51 [0.45–5.05] 0.5038 3.05 [1.36–6.84] 0.0068 1.58 [0.49–5.03] 0.442 1.53 [0.60–3.92] 0.3747
Prostate cancer 3 4208 3.35 [0.14–82.30] 0.4597 1.41 [0.96–2.08] 0.0822 3.25 [0.13–79.90] 0.4707 1.41 [0.93–2.15] 0.1043 1.42 [0.93–2.17] 0.1093
Breast cancer 2 396 0.36 [0.01–8.95] 0.5332 0.35 [0.10–1.24] 0.1045 0.37 [0.02–9.29] 0.5484 0.32 [0.09–1.10] 0.0702 0.30 [0.09–1.00] 0.0495
Lung cancer 2 778 5.41 [2.74–10.69] < 0.0001 1.76 [1.25–2.49] 0.0013 4.51 [2.31–8.81] < 0.0001 2.20 [1.60–3.03] < 0.0001 2.31 [1.77–3.02] < 0.0001
OSCC 2 724 12.68 [1.43–112.64] 0.0227 4.69 [1.96–11.21] 0.0005 10.12 [1.14–89.72] 0.0376 5.17 [1.99–13.43] 0.0008 5.00 [2.10–11.97] 0.0003
Other cancers 6 2045 3.77 [0.15–93.07] 0.4171 1.96 [1.05–3.65] 0.0336 3.10 [0.13–76.51] 0.4887 1.96 [1.05–3.67] 0.0341 1.91 [1.06–3.44] 0.0306
Ethnicity
 Caucasian 8 2666 5.68 [2.57–12.58] < 0.0001 1.43 [0.54–3.74] 0.4691 3.42 [1.57–7.45] 0.002 1.50 [0.58–3.85] 0.3987 1.52 [0.68–3.42] 0.3103
 Asian 10 4914 4.76 [2.55–8.91] < 0.0001 1.94 [1.38–2.72] 0.0001 4.05 [2.1 –7.51] < 0.0001 2.04 [1.44–2.87] < 0.0001 2.03 [1.46–2.81] < 0.0001