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Table 3 Meta-analysis of the HIF1A 1772 C/T polymorphism association with cancer

From: A meta-analysis of hypoxia inducible factor 1-alpha (HIF1A) gene polymorphisms: association with cancers

  TT vs. CC CT vs. CC TT + CT vs. CC TT vs. CT + CC T vs. C
  Study number Sample size OR (95 % CI) p value OR (95 % CI) p value OR (95 % CI) p value OR (95 % CI) p value OR (95 % CI) p value
Overall cancer 22 19024 1.52 [0.73–3.18] 0.2648 1.23 [1.00–1.53] 0.0536 1.30 [1.06–1.59] 0.0115 1.64 [0.94–2.85] 0.0832 1.32 [1.07–1.63] 0.0098
Prostate cancer 6 8688 0.84 [0.47–1.49] 0.5449 1.34 [0.95–1.87] 0.0913 1.33 [0.95–1.87] 0.0982 0.81 [0.47–1.40] 0.4535 1.29 [0.94–1.76] 0.1178
Colorectal cancer 3 3080 1.91 [0.32–11.58] 0.4801 0.83 [0.50–1.39] 0.4817 1.24 [0.77–2.01] 0.3756 1.97 [0.33–11.90] 0.4603 0.94 [0.59–1.49] 0.7833
Renal cancer 3 1145 0.27 [0.08–0.90] 0.0335 0.40 [0.12–1.34] 0.1369 0.43 [0.15–1.20] 0.1082 1.08 [0.44–2.64] 0.8703 0.84 [0.58–1.22] 0.3548
Breast cancer 2 2893 5.18 [0.88–30.38] 0.0683 1.00 [0.77–1.29] 0.9964 1.05 [0.81–1.35] 0.7221 5.18 [0.88–30.36] 0.0684 1.09 [0.86–1.39] 0.4701
Lung cancer 2 778 4.88 [2.42–9.84] < 0.0001 1.56 [0.94–2.61] 0.088 1.67 [0.79–3.54] 0.1832 4.04 [2.02–8.08] < 0.0001 1.68 [0.77–3.64] 0.1908
OSCC 2 922 6.14 [0.25–151.49] 0.2673 1.29 [0.70–2.37] 0.4142 1.36 [0.75–2.49] 0.3127 6.01 [0.24–148.26] 0.2729 1.43 [0.79–2.56] 0.2348
Other cancers 4 1518 27.20 [5.04–146.78] 0.0001 2.16 [1.46–3.18] 0.0056 1.92 [1.17–3.14] 0.0093 17.5 [3.49 – 87.70] 0.0005 2.42 [1.55–3.77] < 0.0001
Ethnicity
 Caucasian 8 6037 0.97 [0.24–3.93] 0.9654 1.09 [0.60–2.00] 0.7751 1.19 [0.75–1.89] 0.4528 1.48 [0.65–3.39] 0.352 1.31 [0.84–2.06] 0.237
 Asian 11 7450 4.98 [2.66–9.31] < 0.0001 1.30 [1.01–1.69 0.0455 1.41 [1.08–1.84] 0.0109 4.28 [2.31–7.95] < 0.0001 1.43 [1.07–1.90] 0.0156
 Mixed 3 5537 0.82 [0.36–1.87] 0.6408 1.16 [1.00–1.65] 0.4178 1.16 [0.79–1.70] 0.4526 0.79 [0.37–1.71] 0.5544 1.14 [0.78–1.67] 0.505