Table 3 Meta-analysis of the HIF1A 1772 C/T polymorphism association with cancer

Overall cancer

22

19024

1.52 [0.73–3.18]

0.2648

1.23 [1.00–1.53]

0.0536

1.30 [1.06–1.59]

0.0115

1.64 [0.94–2.85]

0.0832

1.32 [1.07–1.63]

0.0098

Prostate cancer

6

8688

0.84 [0.47–1.49]

0.5449

1.34 [0.95–1.87]

0.0913

1.33 [0.95–1.87]

0.0982

0.81 [0.47–1.40]

0.4535

1.29 [0.94–1.76]

0.1178

Colorectal cancer

3

3080

1.91 [0.32–11.58]

0.4801

0.83 [0.50–1.39]

0.4817

1.24 [0.77–2.01]

0.3756

1.97 [0.33–11.90]

0.4603

0.94 [0.59–1.49]

0.7833

Renal cancer

3

1145

0.27 [0.08–0.90]

0.0335

0.40 [0.12–1.34]

0.1369

0.43 [0.15–1.20]

0.1082

1.08 [0.44–2.64]

0.8703

0.84 [0.58–1.22]

0.3548

Breast cancer

2

2893

5.18 [0.88–30.38]

0.0683

1.00 [0.77–1.29]

0.9964

1.05 [0.81–1.35]

0.7221

5.18 [0.88–30.36]

0.0684

1.09 [0.86–1.39]

0.4701

Lung cancer

2

778

4.88 [2.42–9.84]

< 0.0001

1.56 [0.94–2.61]

0.088

1.67 [0.79–3.54]

0.1832

4.04 [2.02–8.08]

< 0.0001

1.68 [0.77–3.64]

0.1908

OSCC

2

922

6.14 [0.25–151.49]

0.2673

1.29 [0.70–2.37]

0.4142

1.36 [0.75–2.49]

0.3127

6.01 [0.24–148.26]

0.2729

1.43 [0.79–2.56]

0.2348

Other cancers

4

1518

27.20 [5.04–146.78]

0.0001

2.16 [1.46–3.18]

0.0056

1.92 [1.17–3.14]

0.0093

17.5 [3.49 – 87.70]

0.0005

2.42 [1.55–3.77]

< 0.0001

 Caucasian

8

6037

0.97 [0.24–3.93]

0.9654

1.09 [0.60–2.00]

0.7751

1.19 [0.75–1.89]

0.4528

1.48 [0.65–3.39]

0.352

1.31 [0.84–2.06]

0.237

 Asian

11

7450

4.98 [2.66–9.31]

< 0.0001

1.30 [1.01–1.69

0.0455

1.41 [1.08–1.84]

0.0109

4.28 [2.31–7.95]

< 0.0001

1.43 [1.07–1.90]

0.0156

 Mixed

3

5537

0.82 [0.36–1.87]

0.6408

1.16 [1.00–1.65]

0.4178

1.16 [0.79–1.70]

0.4526

0.79 [0.37–1.71]

0.5544

1.14 [0.78–1.67]

0.505