Circulating micrornas associated with glycemic impairment and progression in Asian Indians

Biomarker Research

Table 4 Odds ratios for microRNA expression associated with glycemic impairment

	Unadjusted			Model 1*			Model 2**
	OR^€	95 % CI	p-value	OR^€	95 % CI	p-value	OR^€	95 % CI	p-value
Prevalent Glycemic Impairment
hsa-miR-191-5p	1.7	1.2, 2.4	0.002	1.6	1.1, 2.3	0.014	1.5	1.1, 2.2	0.026
Progressive Glycemic Impairment After 2.5 Years
hsa-miR-122-5p	0.5	0.2, 0.8	0.003	0.4	0.3, 0.8	0.003	0.5	0.3, 0.8	0.003
hsa-miR-15a-5p	0.6	0.4, 0.9	0.040	0.6	0.4, 0.9	0.031	0.6	0.4, 0.9	0.034
hsa-miR-197-3p	0.6	0.4, 0.9	0.020	0.6	0.4, 0.9	0.016	0.6	0.4, 0.9	0.018
hsa-miR-320a	0.6	0.4, 0.9	0.038	0.6	0.4, 0.9	0.045	0.6	0.4, 0.9	0.032
hsa-miR-423-5p	0.6	0.4, 0.9	0.033	0.6	0.4, 0.9	0.039	0.6	0.4, 0.9	0.030
hsa-miR-486-5p	0.5	0.3, 0.8	0.004	0.4	0.3, 0.8	0.003	0.4	0.3, 0.8	0.003

CI confidence interval, MET metabolic equivalent
^€microRNAs are scaled by quartile
*Model 1 adjusted for age, sex, and waist circumference
**Model 2 adjusted for variables in Model 1 and HDL-cholesterol and triglycerides

ISSN: 2050-7771