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Table 4 Laboratory and clinical characteristics in the CAD group with patients stratified based on prorenin levels

From: Higher plasma prorenin concentration plays a role in the development of coronary artery disease

 

Prorenin ≥ 1,100

Prorenin < 1,100

p-value

(n = 15)

(n = 44)

Age, years

72 ± 6

67 ± 9

0.047

Body mass index

24.4 ± 3.3

23.7 ± 2.9

0.43

Prorenin (ng/ml)

1521 (1261–1937)

435 (227–601)

<0.001

Plasma renin concentration (pg/ml)

12.1 (6.9 - 17.5)

5.6 (4.1 - 8.5)

0.001

Plasma renin activity (ng/ml/hr)

2.3 (1.1 - 4.2)

0.8 (0.6 - 1.6)

0.017

Aldosterone (pg/ml)

82 (69–92)

69 (58–104)

0.63

Brain natriuretic peptide (ng/ml)

43 (24–76)

25 (12–60)

0.23

Cystatin C (mg/dl)

1.19 ± 0.54

1.05 ± 0.29

0.21

Creatinine (mg/ml)

0.91 ± 0.34

0.83 ± 0.24

0.32

Estimated GFR (ml/min/1.73 m2)

65.8 ± 21.8

70.9 ± 18.3

0.38

Blood urea nitrogen (mg/dl)

17.2 ± 4.5

15.4 ± 3.9

0.16

Hemoglobin A1c (%)

6.2 ± 0.7

6.0 ± 1.2

0.67

Total cholesterol (mg/dl)

178 ± 33

191 ± 33

0.19

LDL cholesterol (mg/dl)

101 ± 29

115 ± 31

0.14

HDL cholesterol (mg/dl)

49 ± 12

48 ± 14

0.74

Triglycerides (mg/dl)

141 ± 60

138 ± 77

0.91

C-reactive protein (mg/dl)

0.13 ± 0.17

0.20 ± 0.22

0.32

Total protein (g/dl)

6.80 ± 0.24

6.70 ± 0.42

0.43

Albumin (g/dl)

4.15 ± 0.24

4.12 ± 0.32

0.74

Sodium (mEq/l)

139.6 ± 2.8

140.6 ± 2.1

0.13

Potassium (mEq/l)

4.27 ± 0.37

3.97 ± 0.32

0.005

Cl (mEq/l)

104.9 ± 3.8

105.5 ± 2.7

0.42

  1. Numerical data are expressed as the mean ± one standard deviation. Non-parametric data are expressed as the median (interquartile range). GFR: glomerular filtration rate