From: Higher plasma prorenin concentration plays a role in the development of coronary artery disease
Prorenin ≥ 1,100 | Prorenin < 1,100 | p-value | |
---|---|---|---|
(n = 15) | (n = 44) | ||
Age, years | 72 ± 6 | 67 ± 9 | 0.047 |
Body mass index | 24.4 ± 3.3 | 23.7 ± 2.9 | 0.43 |
Prorenin (ng/ml) | 1521 (1261–1937) | 435 (227–601) | <0.001 |
Plasma renin concentration (pg/ml) | 12.1 (6.9 - 17.5) | 5.6 (4.1 - 8.5) | 0.001 |
Plasma renin activity (ng/ml/hr) | 2.3 (1.1 - 4.2) | 0.8 (0.6 - 1.6) | 0.017 |
Aldosterone (pg/ml) | 82 (69–92) | 69 (58–104) | 0.63 |
Brain natriuretic peptide (ng/ml) | 43 (24–76) | 25 (12–60) | 0.23 |
Cystatin C (mg/dl) | 1.19 ± 0.54 | 1.05 ± 0.29 | 0.21 |
Creatinine (mg/ml) | 0.91 ± 0.34 | 0.83 ± 0.24 | 0.32 |
Estimated GFR (ml/min/1.73 m2) | 65.8 ± 21.8 | 70.9 ± 18.3 | 0.38 |
Blood urea nitrogen (mg/dl) | 17.2 ± 4.5 | 15.4 ± 3.9 | 0.16 |
Hemoglobin A1c (%) | 6.2 ± 0.7 | 6.0 ± 1.2 | 0.67 |
Total cholesterol (mg/dl) | 178 ± 33 | 191 ± 33 | 0.19 |
LDL cholesterol (mg/dl) | 101 ± 29 | 115 ± 31 | 0.14 |
HDL cholesterol (mg/dl) | 49 ± 12 | 48 ± 14 | 0.74 |
Triglycerides (mg/dl) | 141 ± 60 | 138 ± 77 | 0.91 |
C-reactive protein (mg/dl) | 0.13 ± 0.17 | 0.20 ± 0.22 | 0.32 |
Total protein (g/dl) | 6.80 ± 0.24 | 6.70 ± 0.42 | 0.43 |
Albumin (g/dl) | 4.15 ± 0.24 | 4.12 ± 0.32 | 0.74 |
Sodium (mEq/l) | 139.6 ± 2.8 | 140.6 ± 2.1 | 0.13 |
Potassium (mEq/l) | 4.27 ± 0.37 | 3.97 ± 0.32 | 0.005 |
Cl (mEq/l) | 104.9 ± 3.8 | 105.5 ± 2.7 | 0.42 |