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Fig. 3 | Biomarker Research

Fig. 3

From: Detection of BCR-ABL T315I mutation by peptide nucleic acid directed PCR clamping and by peptide nucleic acid FISH

Fig. 3

Detection of BCR-ABL T315I mutation by PNA. Detection of BCR-ABL T315I mutation by PNA (green signal) in CD34+ cells enriched from CML patients carrying T315I mutation. Panel a and b show T315I positive cells from a patient with 60 % of mutated cells positive cells, panel c and d show T315I positive cells from a patient with 45 % of mutated cells. Negative control (e, f) is represented by a CML patient without T315I mutation. No specific PNA green signal can be detected in the absence of the mutation

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