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Fig. 2 | Biomarker Research

Fig. 2

From: Characterization of medulloblastoma in Fanconi Anemia: a novel mutation in the BRCA2 gene and SHH molecular subgroup

Fig. 2

Imaging and Histopatological features of MB2. MRI. Axial T2-weighted image (a) and sagittal T1-weighted image (b) show a nodular mass originating from the vermis and bulging into the fourth ventricle. Apparent diffusion coefficient (ADC) map (c) shows lack of diffusion restriction. Perfusion weighted imaging (d) reveals hyperperfusion within the lesion. (e) Tumor is characterized by pleomorphic cells with large nuclei, prominent nucleoli and moderate eosinophilic cytoplasm. (f) Large cells show immunoreactivity for synaptophysin. (g) N-Myc oncogene amplification (green spots) detected in neoplastic nuclei (blue) and centromere 8 signals (red spots) using CEP8/BAC as FISH probes. Red arrow: N-Myc amplified cell. White arrow: N-Myc dyploid cell

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