A panel of DNA methylation markers reveals extensive methylation in histologically benign prostate biopsy cores from cancer patients

Table 3 AUCs for training and test data

*Without methylation level as a covariate*			*With methylation level as a covariate*
*Model*	*Area under ROC using training data (44 controls; 24 cases)*	*Area under ROC using test Data (23 controls; 13 cases)*	*Model*	*Area under ROC using training data (44 controls; 24 cases)*	*Area under ROC using test data (23 controls; 13 cases)*
1 Covariate models			1 Covariate models
HOXD9	0.82	0.74	RASSF5	0.84	0.88
CXCL14	0.82	0.86	HOXD9	0.88	0.92
APC	0.87	0.76	APC	0.88	0.77
RASSF1	0.87	0.83	RASSF1	0.91	0.91
ADCY4	0.9	0.91	ADCY4	0.96	0.98
2 Covariate models			2 Covariate models
ADCY4 + KIFC2	0.97	0.97	ADCY4 + LOXL2	0.98	0.98
RASSF1 + ADCY4	0.96	0.95	ADCY4 + age	0.98	0.98
APC + ADCY4	0.96	0.97	ADCY4 + RASSF1	0.99	0.97
RASSF1 + APC	0.97	0.89	ADCY4 + SOCS3	0.98	0.99
RASSF5 + ADCY4	0.96	0.96	ADCY4 + KIFC2	0.99	0.99
3 Covariate models			3 Covariate models
KIFC2 + RASSF5 + HAPLN3	0.99	0.97	KIFC2 + CXCL14 + GSTP1	0.99	0.94
HOXB5 + APC + RASSF1	0.99	0.98	KIFC2 + ADCY4 + PTGS2	0.99	0.99
ADCY4 + KIFC2 + HAPLN3	0.99	0.98	CYBA + ADCY4 + KIFC2	0.99	0.99
APC + RASSF5 + CXCL14	0.99	0.98	KIFC2 + ADCY4 + CXCL14	1.00	0.99
KIFC2 + RASSF5 + CXCL14	0.99	0.98	SOCS3 + APC + RARB	1.00	0.94

Shows the area under the ROC based upon training data and test data using varying degrees of model complexity. Models consider a yes/no indicator for methylation (>0) of each individual marker or use the level of methylation as a covariate.

ISSN: 2050-7771