Figure 2

Examples of receiver operating characteristics (ROC) curves obtained with markers that were commonly methylated in CCNC cores. The data is shown for HOXB5, and then HOXB5 combined sequentially with up to 4 markers as shown in the list above. (A) shows the ROC curve obtained when the methylation data for the cancer cores and the methylation data of the most methylated core from controls were used. (B) shows the ROC curve when the data for the cancer cores is replaced with the methylation of the CCNC core for each cancer patient. In cases where more than one CCNC core was available, the most methylated core was selected for analysis.