Figure 1

Receiver operating characteristics (ROC) curves based on the number of methylated markers and their methylation levels generated with the data used to estimate the sensitivity and specificity in Table 2 . (A) shows the ROC curves obtained when the methylation data for the cancer cores and the methylation data of the most methylated core from controls were used. (B) shows the ROC curves when the data for the cancer cores is replaced with the methylation of the CCNC core for each cancer patient. In cases where more than one CCNC core was available, the most methylated core was selected for analysis. Using 5 positive markers out of 24 to identify a cancer case yielded AUCs of 0.998 and 0.802 for cancer and CCNC cores, respectively.