Table 1 Antibodies in paraneoplastic neurologic syndromes
From: The great masquerader of malignancy: chronic intestinal pseudo-obstruction
Antibody | Paraneoplastic neurologic syndrome | Associated malignancies |
|---|---|---|
Anti-Hu (ANNA-1) | Encephalomyelitis, cerebellar degeneration, sensory neuronopathy, autonomic dysfunction | SCLC |
Anti-Yo (PCA-1) | Cerebellar degeneration | Gynecological, breast |
Anti-Ri (ANNA-2) | Cerebellar degeneration, opsoclonus-myoclonus | Gynecological, breast, SCLC |
Anti-Tr (DNER) | Cerebellar degeneration | Hodgkin lymphoma |
Anti-amphiphysin | Stiff-person syndrome | Breast, lung cancer |
Anti-Ma2 (Ta) | Limbic encephalitis | Teratoma, lung cancer |
Anti-CRMP5 (CV2) | Encephalomyelitis, peripheral neuropathy | SCLC, thymoma |
Anti-recoverin | Retinopathy | SCLC |
Anti-VGCC | Lambert-Eaton syndrome | SCLC |
Anti-VGKC | Neuromyotonia | Thymoma |
Hodgkin lymphoma | ||
SCLC | ||
Anti-AChR | Myasthenia gravis | Thymoma |
Anti-titin | ||
Anti-ryanodine | ||
Anti-JO1 | Inflammatory myopathies | Ovarian cancer |
Anti-Mi2 | Lung cancer | |
Anti-p155 | Gastric cancer | |
Non-Hodgkin lymphoma |